Abstract | BACKGROUND: METHODS: In prospective randomized controlled trial, 120 patients with overt HE were randomized in two groups: group A lactulose plus albumin (n = 60) and group B lactulose alone (n = 60). Primary end point was complete reversal of HE, and secondary end points were mortality and hospital stay. RESULTS: A total of 120 patients (mean age 40.4 ± 9.3 years) were included in this study. Thirty-six (30%) patients were in Child-Turcotte-Pugh ( CTP) class B, and 84 (70%) were in CTP Class C. Mean CTP score was 9.8 ± 2.1, and model for end-stage liver disease score was 26.1 ± 5.3. Twenty seven (22.5%) had grade 2, 57 (47.5%) had grade 3, and 36 (30%) had grade 4 HE at the time of admission. Forty-five (75%) patients in group A compared with 32 (53.3%) patients in group B had complete reversal of HE (P = 0.03). Mortality was significantly lower in lactulose plus albumin group (11[18.3%]) versus lactulose alone (19 [31.6%], [P < 0.05]). There was significant decrease in levels of arterial ammonia, interleukin-6, interleukin-18, tumor necrosis factor-alpha, and endotoxins after treatment in both groups; however, the delta decrease was significantly higher in group A compared with group B. Hospital stay was shorter in group A. CONCLUSIONS:
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Authors | Barjesh Chander Sharma, Jatinderpal Singh, Siddharth Srivastava, Alok Sangam, Alok Kumar Mantri, Nirupma Trehanpati, Shiv Kumar Sarin |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 32
Issue 6
Pg. 1234-1239
(Jun 2017)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 27885712
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | © 2016 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. |
Chemical References |
- Albumins
- Biomarkers
- Endotoxins
- Interleukin-18
- Interleukin-6
- Tumor Necrosis Factor-alpha
- Lactulose
- Ammonia
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Topics |
- Adult
- Albumins
(administration & dosage)
- Ammonia
(blood)
- Biomarkers
(blood)
- Drug Therapy, Combination
- Endotoxins
(blood)
- Female
- Hepatic Encephalopathy
(diagnosis, drug therapy, mortality)
- Humans
- Interleukin-18
(blood)
- Interleukin-6
(blood)
- Lactulose
(administration & dosage)
- Male
- Middle Aged
- Prospective Studies
- Treatment Outcome
- Tumor Necrosis Factor-alpha
(blood)
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