[Analysis of minocycline hydrochloride combined with Vitapex in treating senile chronic periodontal-endodontic combined lesions].

Abstract

PURPOSE:

To investigate the effect of minocycline hydrochloride combined with Vitapex in treating senile chronic periodontal-endodontic combined lesions.

METHODS:

One hundred twenty patients with senile chronic periodontitis and endodontic lesions patients treated in our hospital between Jun.2012 to Jun.2014 were selected. They were divided into experimental group (n=60) and control group (n=60). Patients in the control group were given conventional root canal therapy, while patients in the experimental group were given Vitapex and minocycline hydrochloride. The clinical effect between two groups was compared. SPSS18.0 software package was used for statistical analysis.

RESULTS:

Compared with pre-treatment, the levels of IL-17, TNF-α and CRP in serum were decreased in two groups, but the levels in the experimental group were significantly lower than those in the control group(P<0.05). Compared with pre-treatment, PD, GI, BI, PLI were decreased in two groups, but the levels in the experimental group were significantly lower than those in the control group(P<0.05). The effective rate of experimental group was 83.33% and the control group was 68.33%, the difference was statistically significant (P<0.05).

CONCLUSIONS:

For chronic periodontitis and endodontic lesions, besides conventional root canal therapy, Vitapex combined with minocycline hydrochloride can significantly improve the clinical effect.

• Authors: Zhen-Yu Liu, Jing-Dong Zhang, Lin Zhang, Jian Yang, Xiang-Hui Liu
• Journal: Shanghai kou qiang yi xue = Shanghai journal of stomatology (Shanghai Kou Qiang Yi Xue) Vol. 25 Issue 4 Pg. 465-468 (Aug 2016) ISSN: 1006-7248 [Print] China
• PMID: 27858072 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Anti-Bacterial Agents
• IL17A protein, human
• Interleukin-17
• Root Canal Filling Materials
• Silicones
• Tumor Necrosis Factor-alpha
• calcium hydroxide, iodoform, silicone oil drug combination
• Minocycline
• Calcium Hydroxide

Topics

• Anti-Bacterial Agents (therapeutic use)
• Calcium Hydroxide (therapeutic use)
• Chronic Periodontitis (therapy)
• Dental Scaling
• Humans
• Interleukin-17
• Minocycline (therapeutic use)
• Root Canal Filling Materials (therapeutic use)
• Root Canal Therapy
• Silicones (therapeutic use)
• Tumor Necrosis Factor-alpha