Osteotropic peptide-mediated bone targeting for photothermal treatment of bone tumors.

Abstract

The treatment of bone tumors is a challenging problem due to the inefficient delivery of therapeutics to bone and the bone microenvironment-associated tumor resistance to chemo- and radiotherapy. Here, we developed a bone-targeted nanoparticle, aspartate octapeptide-modified dendritic platinum-copper alloy nanoparticle (Asp-DPCN), for photothermal therapy (PTT) of bone tumors. Asp-DPCN showed much higher affinity toward hydroxyapatite and bone fragments than the non-targeted DPCN in vitro. Furthermore, Asp-DPCN accumulated more efficiently around bone tumors in vivo, and resulted in a higher temperature in bone tumors during PTT. Finally, Asp-DPCN-mediated PTT not only efficiently depressed the tumor growth but also significantly reduced the osteoclastic bone destruction. Our study developed a promising therapeutic approach for the treatment of bone tumors.

• Authors: Yitong Wang, Jian Yang, Hongmei Liu, Xinyu Wang, Zhengjie Zhou, Quan Huang, Dianwen Song, Xiaopan Cai, Lin Li, Kaili Lin, Jianru Xiao, Peifeng Liu, Qiang Zhang, Yiyun Cheng
• Journal: Biomaterials (Biomaterials) Vol. 114 Pg. 97-105 (01 2017) ISSN: 1878-5905 [Electronic] Netherlands
• PMID: 27855337 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2016 Elsevier Ltd. All rights reserved.

Chemical References

• Nanocapsules
• Oligopeptides

Topics

• Animals
• Bone Neoplasms (metabolism, pathology, therapy)
• Cell Line, Tumor
• Hyperthermia, Induced (methods)
• Male
• Metal Nanoparticles (administration & dosage, therapeutic use)
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Molecular Targeted Therapy (methods)
• Nanocapsules (administration & dosage, therapeutic use)
• Oligopeptides (administration & dosage, pharmacokinetics)
• Phototherapy (methods)
• Treatment Outcome