Abstract | BACKGROUND: METHODS: Nationwide, retrospective, register based cohort study of 520,859 children born in Denmark 1997-2006, who were followed from 15months to 4years of age. Incidence rate ratios (IRRs) of hospital admissions were estimated by Cox regression and adjusted for background factors including exact age. RESULTS: By 2years of age, 4965 children had simultaneous MMR and DTaP-IPV-Hib as their most recent vaccination. Compared with MMR alone, simultaneous administration was associated with a higher rate of lower respiratory tract infections (adjusted incidence rate ratio ( IRR), 1.27; 95% confidence interval (CI), 1.13-1.42). There was no effect on other infections. Overall, simultaneous administration was associated with a 7% (95% CI, 0-15%) increase in infectious disease admissions. CONCLUSIONS: Simultaneous administration of MMR and DTaP-IPV-Hib compared with MMR alone may increase the rate of hospital admissions related to lower respiratory tract infections. These findings require replication in other high-income settings.
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Authors | Signe Sørup, Christine S Benn, Anja Poulsen, Tyra G Krause, Peter Aaby, Henrik Ravn |
Journal | Vaccine
(Vaccine)
Vol. 34
Issue 50
Pg. 6172-6180
(12 07 2016)
ISSN: 1873-2518 [Electronic] Netherlands |
PMID | 27840013
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved. |
Chemical References |
- DTP-IPV-Hib vaccine
- Diphtheria-Tetanus-Pertussis Vaccine
- Haemophilus Vaccines
- Measles-Mumps-Rubella Vaccine
- Poliovirus Vaccine, Inactivated
- Vaccines, Combined
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Topics |
- Child, Preschool
- Denmark
(epidemiology)
- Diphtheria-Tetanus-Pertussis Vaccine
(administration & dosage, immunology)
- Female
- Haemophilus Vaccines
(administration & dosage, immunology)
- Hospitalization
- Humans
- Immunization Schedule
- Incidence
- Infant
- Male
- Measles-Mumps-Rubella Vaccine
(administration & dosage, immunology)
- Poliovirus Vaccine, Inactivated
(administration & dosage, immunology)
- Respiratory Tract Infections
(epidemiology)
- Retrospective Studies
- Vaccines, Combined
(administration & dosage, immunology)
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