Abstract | BACKGROUND: METHODS: RESULTS: The rates of the simultaneous presence of interleukin-1 polymorphisms and Helicobacter pylori-seropositivity between non-ST-segment elevation acute coronary syndrome and ST-segment elevation myocardial infarction groups were 25.7% and 42.7%, respectively (P = 0.012). Helicobacter pylori-seropositive subjects with interleukin-1 polymorphisms showed significantly higher levels of high sensitivity C-reactive protein (0.04-0.12 vs. 0.02-0.05; P<0.001). Multivariate logistic regression analysis revealed that the carriage of Helicobacter pylori-seropositivity and interleukin-1 polymorphisms was significantly associated with ST-segment elevation myocardial infarction (odds ratio, 2.32; 95% confidence interval, 1.23-4.37; P = 0.009). The C-statistic of conventional risk factors was 0.68 (P<0.001) and that including Helicobacter pylori-seropositivity and interleukin-1 polymorphisms was 0.70 (P<0.001); continuous net reclassification improvement was 34% (P = 0.0094) and integrated discrimination improvement was 3.0% (P = 0.014). CONCLUSIONS:
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Authors | Noriaki Tabata, Daisuke Sueta, Tomonori Akasaka, Yuichiro Arima, Kenji Sakamoto, Eiichiro Yamamoto, Yasuhiro Izumiya, Megumi Yamamuro, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Kazunori Morita, Kentaro Oniki, Junji Saruwatari, Kazuko Nakagawa, Seiji Hokimoto |
Journal | PloS one
(PLoS One)
Vol. 11
Issue 11
Pg. e0166240
( 2016)
ISSN: 1932-6203 [Electronic] United States |
PMID | 27832202
(Publication Type: Journal Article)
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Chemical References |
- Interleukin-1beta
- C-Reactive Protein
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Topics |
- Acute Coronary Syndrome
(complications, genetics, virology)
- Aged
- Aged, 80 and over
- C-Reactive Protein
(analysis)
- Female
- Helicobacter Infections
(complications)
- Helicobacter pylori
(isolation & purification)
- Humans
- Interleukin-1beta
(genetics)
- Male
- Middle Aged
- Polymorphism, Genetic
- Risk Factors
- ST Elevation Myocardial Infarction
(complications, genetics, virology)
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