Inflammasomes and dermatology.

Abstract

Inflammasomes are intracellular multiprotein complexes that comprise part of the innate immune response. Since their definition, inflammasome disorders have been linked to an increasing number of diseases. Autoinflammatory diseases refer to disorders in which local factors lead to the activation of innate immune cells, causing tissue damage when in the absence of autoantigens and autoantibodies. Skin symptoms include the main features of monogenic inflammasomopathies, such as Cryopyrin-Associated Periodic Syndromes (CAPS), Familial Mediterranean Fever (FMF), Schnitzler Syndrome, Hyper-IgD Syndrome (HIDS), PAPA Syndrome, and Deficiency of IL-1 Receptor Antagonist (DIRA). Concepts from other pathologies have also been reviewed in recent years, such as psoriasis, after the recognition of a combined contribution of innate and adaptive immunity in its pathogenesis. Inflammasomes are also involved in the response to various infections, malignancies, such as melanoma, autoimmune diseases, including vitiligo and lupus erythematosus, atopic and contact dermatitis, acne, hidradenitis suppurativa, among others. Inhibition of the inflammasome pathway may be a target for future therapies, as already occurs in the handling of CAPS, through the introduction of IL-1 inhibitors. This study presents a literature review focusing on the participation of inflammasomes in skin diseases.

• Authors: Daniel Coelho de Sá, Cyro Festa Neto
• Journal: Anais brasileiros de dermatologia (An Bras Dermatol) 2016 Sep-Oct Vol. 91 Issue 5 Pg. 566-578 ISSN: 1806-4841 [Electronic] Spain
• PMID: 27828627 (Publication Type: Journal Article, Review)

Chemical References

• Inflammasomes
• Interleukin-1beta

Topics

• Hereditary Autoinflammatory Diseases (immunology)
• Humans
• Immunity, Innate (immunology)
• Inflammasomes (immunology)
• Interleukin-1beta (immunology)
• Skin Diseases (immunology, pathology)