Electrophysiological assessment of Guillain-Barré syndrome with both Gal-C and ganglioside antibodies; tendency for demyelinating type.

Abstract

Whether patients who have GBS with antibodies to galactocerebroside (Gal-C) and gangliosides (Gal-C-GS-GBS) more often have demyelinating or axonal neuropathy remains controversial. We assessed the electrophysiological data from 16 patients with Gal-C-GS-GBS based on the two established criteria to clarify this issue. In this largest cohort of Gal-C-GS-GBS, eight patients had demyelinating neuropathy and none exhibited axonal neuropathy on either criterion. These data indicated that antibodies to Gal-C, a myelin antigen, might predominantly be associated with demyelinating neuropathy, even in the presence of concomitant antibodies to gangliosides.

• Authors: Makoto Samukawa, Motoi Kuwahara, Miyuki Morikawa, Rino Ueno, Yukihiro Hamada, Kazuo Takada, Makito Hirano, Yoshiyuki Mitsui, Masahiro Sonoo, Susumu Kusunoki
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 301 Pg. 61-64 (12 15 2016) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 27823807 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2016 Elsevier B.V. All rights reserved.

Chemical References

• Autoantibodies
• Cytokines
• Galactosylceramides
• Gangliosides
• galactocerebroside

Topics

• Action Potentials (physiology)
• Adult
• Aged
• Aged, 80 and over
• Autoantibodies (blood)
• Child
• Cytokines (blood)
• Enzyme-Linked Immunosorbent Assay
• Female
• Galactosylceramides (immunology)
• Gangliosides (immunology)
• Guillain-Barre Syndrome (blood, diagnosis, physiopathology)
• Humans
• Longitudinal Studies
• Male
• Middle Aged
• Mycoplasma pneumoniae (immunology)
• Neural Conduction (physiology)