HPIP expression predicts chemoresistance and poor clinical outcomes in patients with epithelial ovarian cancer.

Abstract	This study aims to investigate the expression of the hematopoietic pre-B-cell leukemia transcription factor-interacting protein (HPIP) and its association with platinum resistance in epithelial ovarian cancer (EOC). The protein expression of HPIP was analyzed by immunohistochemistry in 248 patients with EOC. Furthermore, we analyzed the association between HPIP expression and clinicopathological features including prognosis in EOC samples. High HPIP expression was correlated with platinum resistance in EOCs. HPIP in platinum-resistant cases was overexpressed compared with that in platinum-sensitive cases (P<.001). Platinum resistance was independently correlated with the International Federation of Gynecology and Obstetrics stage and HPIP overexpression. High HPIP expression was positively correlated with International Federation of Gynecology and Obstetrics stage, histologic grade, residual tumor size, lymph node metastasis, serum levels of CA125, and poor prognosis. Our findings indicate that HPIP overexpression is an independent predictor of platinum-based chemotherapy resistance and that it may also be a potential biomarker for targeted therapy.
Authors	Yao Wang, Mingxun Li, Fanling Meng, Ge Lou
Journal	Human pathology (Hum Pathol) Vol. 60 Pg. 114-120 (02 2017) ISSN: 1532-8392 [Electronic] United States
PMID	27818289 (Publication Type: Journal Article)
Copyright	Copyright © 2016 Elsevier Inc. All rights reserved.
Chemical References	Biomarkers, Tumor CA-125 Antigen HCFC1R1 protein, human Intracellular Signaling Peptides and Proteins MUC16 protein, human Membrane Proteins Platinum Compounds
Topics	Antineoplastic Combined Chemotherapy Protocols (therapeutic use) Biomarkers, Tumor (analysis, blood) Biopsy CA-125 Antigen (blood) Carcinoma, Ovarian Epithelial Disease-Free Survival Drug Resistance, Neoplasm Female Humans Immunohistochemistry Intracellular Signaling Peptides and Proteins (analysis) Kaplan-Meier Estimate Lymphatic Metastasis Membrane Proteins (blood) Middle Aged Neoplasm Grading Neoplasm Staging Neoplasms, Glandular and Epithelial (chemistry, drug therapy, pathology) Ovarian Neoplasms (chemistry, drug therapy, pathology) Platinum Compounds (therapeutic use) Predictive Value of Tests Proportional Hazards Models Time Factors Treatment Outcome Tumor Burden Up-Regulation

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