Antiphosphatidylserine/prothrombin antibodies as biomarkers to identify severe primary antiphospholipid syndrome.

Abstract

BACKGROUND:

Anti-phosphatidylserine/prothrombin (aPS/PT) antibodies have begun to be considered potentional biomarkers for antiphospholipid syndrome (APS). This cohort study investigate the role of aPS/PT antibodies as a risk factor for severe APS by evaluating the association between those antibodies and clinical/laboratory profiles of APS.

METHODS:

Plasma/serum samples from 197 APS patients, 100 healthy subjects and 106 patients with autoimmune diseases were collected. IgG/IgM aPS/PT antibodies were assayed using commercial ELISA kit.

RESULTS:

Prevalences of IgG and IgM aPS/PT (p<0.0001 and p=0.0009, respectively) and their titres (p<0.0001 and p=0.0002, respectively) were significantly higher in thrombosis/pregnancy group with respect to pregnancy morbidity alone. Prevalences of IgG and IgM aPS/PT (p<0.0001 and p=0.0004, respectively) and their mean levels (p=0.0001 for both) were significantly higher in the prematurity linked to life-threatening obstetric complications group with respect to miscarriage group. There was a significant relationship between IgG and IgM aPS/PT (p=0.001 and p=0.0002) and their mean levels were higher (p=0.0004 and p=0.0002, respectively) in the thrombotic microangiopathy group, considered a milestone manifestation of catastrophic APS. The relationship between IgG and IgM aPS/PT was significant and mean levels were higher in triple positive antiphospholipid antibody patients than in double and single positivity ones (p<0.0001 for all).

CONCLUSIONS:

APS/PT antibodies were associated to severe thrombosis, severe pregnancy complications inducing prematurity, and vascular microangiopathy, all generally associated to high risk APS forms requiring strong therapy.

• Authors: Ariela Hoxha, Elena Mattia, Marta Tonello, Chiara Grava, Vittorio Pengo, Amelia Ruffatti
• Journal: Clinical chemistry and laboratory medicine (Clin Chem Lab Med) Vol. 55 Issue 6 Pg. 890-898 (May 01 2017) ISSN: 1437-4331 [Electronic] Germany
• PMID: 27816952 (Publication Type: Journal Article)

Chemical References

• Antibodies, Antiphospholipid
• Biomarkers
• Phosphatidylserines
• Prothrombin

Topics

• Adult
• Antibodies, Antiphospholipid (blood, immunology)
• Antiphospholipid Syndrome (blood, immunology)
• Biomarkers (blood)
• Female
• Humans
• Male
• Middle Aged
• Phosphatidylserines (immunology)
• Pregnancy
• Prothrombin (immunology)
• Retrospective Studies