Role of Risorine in the Treatment of Drug - Susceptible Pulmonary Tuberculosis: A Pilot Study.

Abstract

OBJECTIVE:

To study the efficacy and tolerability of Risorine Capsule (A fixed dose combination of Rifampicin 200 mg + INH 300 mg + Piperine 10 mg) therapy in the treatment of drug-susceptible pulmonary tuberculosis patients who developed GI intolerance with standard WHO anti TB regimen.

METHODS:

33 patients with pulmonary tuberculosis were treated with one Risorine kit, daily consisting of one capsule of Risorine, one tablet of ethambutol (800 mg) and two tablets of Pyrazinamide 750 mg each, for first two months of therapy. All the patients received one capsule of Risorine daily for next four months. Symptomatic improvement, Sputum conversion and radiological improvement were monitored at regular intervals.

RESULTS:

Out of 27 patients who were sputum positive at baseline, 24 patients became sputum negative during the first two months of treatment. Out remaining three patients, one became sputum negative at the end of third month of treatment and the other two became sputum negative at the end of sixth month of treatment. Out of 33 patients, only two patients developed mild nausea, which subsided spontaneously. One patient who was HIV positive, developed hepatitis.

CONCLUSIONS:

Risorine, a novel formulation of rifampicin 200 mg with bioenhancer piperine 10mg, is found to be highly effective and well tolerated in the treatment of drug - susceptible pulmonary tuberculosis.

• Authors: Agam Vora, Sanjay Patel, Kamlesh Patel
• Journal: The Journal of the Association of Physicians of India (J Assoc Physicians India) Vol. 64 Issue 11 Pg. 20-24 (Nov 2016) ISSN: 0004-5772 [Print] India
• PMID: 27805329 (Publication Type: Journal Article)

Chemical References

• Alkaloids
• Antitubercular Agents
• Benzodioxoles
• Cytochrome P-450 Enzyme Inhibitors
• Drug Combinations
• Piperidines
• Polyunsaturated Alkamides
• Pyrazinamide
• Ethambutol
• piperine
• Isoniazid
• Rifampin

Topics

• Adult
• Alkaloids (administration & dosage)
• Antitubercular Agents (administration & dosage)
• Benzodioxoles (administration & dosage)
• Cytochrome P-450 Enzyme Inhibitors (administration & dosage)
• Drug Combinations
• Ethambutol (administration & dosage)
• Female
• Humans
• Isoniazid (administration & dosage)
• Male
• Middle Aged
• Pilot Projects
• Piperidines (administration & dosage)
• Polyunsaturated Alkamides (administration & dosage)
• Pyrazinamide (administration & dosage)
• Rifampin (administration & dosage)
• Tuberculosis, Pulmonary (drug therapy)
• Young Adult