Metal-organic complexes (MOCs) are emerging developing functional materials, the different categories of
metal ions and organic biomolecules provide great possibilities for the morphologies, sizes, and properties of the products. Enlightened by the previous works of
folate-
nickel nanotubes (FA-Ni NTs), herein, a series of
metal ions are tested to coordinate with
folate (FA) by the solvothermal method, among which the
folate-
cobalt(II) complex is formed to be a scaffold for the nanotube with the length of 150-500 nm and inner diameter of 6-11 nm, while the other
metal ions fail. In vitro experiments reveal that
folate-
cobalt nanotubes (FA-Co NTs) have excellent antitumor activity toward
tumor cells with high expression levels of
folate receptor (FR), whereas they show extremely low toxicity to normal cells. Furthermore, these kinds of NTs show better antitumor ability when the anticancer
drug doxorubicin is encapsulated through
cell surface receptor-mediated endocytosis. Moreover, we study the fundamental pharmacokinetic profiles and biodistribution of FA-Co NTs on mice and also prove its targeting capability to
tumor tissues on
tumor-bearing mice using the radioactive
iodine-131 (131I) tracing method. FA-Co NTs can also markedly inhibit the growth of
tumor with minimal side effects when administered individually in vivo. These findings will expand the research on FA based
metal complex nanomaterials as a kind of potential antitumor nanomedicine as well as a targeted
drug carrier.