Radiofrequency in the Management of Colorectal Liver Metastases: A 10-Year Experience at a Single Center.

Abstract

BACKGROUND:

Liver resection is the curative treatment for patients with colorectal liver metastases (CRLMs), with five-year survival rates of 30-50%. Radiofrequency ablation (RFA) is a local and useful alternative for patients with non-resectable CRLMs to obtain complete tumor clearance. The aim of this study was to analyze survival rates with this local treatment.

MATERIALS AND METHODS:

All patients who underwent RFA and resection or RFA alone for unresectable CRLMs between 2001 and 2012 were included in a retrospective study. Descriptive and survival statistics were calculated. Morbidity, mortality, and recurrence were also analyzed.

RESULTS:

The study involved 72 patients and 179 lesions. RFA was performed in 109 procedures. Mortality was 2.7% and morbidity was 25.7%. Local recurrence concerned 25.7% of lesions. Independent risk factors for recurrence were more than one CRLM (p= 0.0427) and size of largest CRLM greater than 3 cm (p= 0.0139). The five-year overall survival rate was 45.5% and the five-year disease-free survival (DFS) was 9.9%.

CONCLUSION:

This study shows RFA has good oncological outcomes. The combination of RFA and resection is considered as a curative treatment for patients with unresectable CRLMs.

• Authors: Sandra Aissou, Victoire Cartier, Antoine Hamy, Fleur Plumereau, Christophe Aube, Emilie Lermite
• Journal: Surgical technology international (Surg Technol Int) Vol. 29 Pg. 99-105 (Oct 26 2016) ISSN: 1090-3941 [Print] United States
• PMID: 27780345 (Publication Type: Journal Article)

Topics

• Catheter Ablation
• Colorectal Neoplasms (pathology)
• Hepatectomy
• Humans
• Liver Neoplasms (secondary, therapy)
• Neoplasm Recurrence, Local
• Retrospective Studies
• Treatment Outcome