Abstract | OBJECTIVES: DESIGN: This study analyzed these proteins in 30 cases of SA, 10 cases of UA, and 30 cases of AOT. Immunoexpression was evaluated in the parenchyma and stroma by attributing the following scores: 0, no stained cells; 1, ≤10%; 2, >10% and ≤25%; 3, >25% and ≤50%; 4, >50% and ≤75%.; 5, >75% stained cells. RESULTS: In SAs, positive correlations were observed between the stromal and parenchymal expression of BMP-2 (p<0.001) and between the stromal expression of BMP-2 and BMP-4 (p=0.020), as well as between the stromal expression of BMPR-II and BMP-4 (p=0.001) and the stromal and parenchymal expression of BMPR-II (p<0.001). In UAs, correlations were detected between the stromal and parenchymal expression of BMP-4 (p=0.035) and between the stromal expression of BMP-4 and BMPR-IA (p=0.022). In AOTs, analysis of immunoexpression in the parenchyma revealed positive correlations between all proteins. CONCLUSION: BMPs and their receptors play an important role in the differentiation and development of ameloblastomas and AOTs, but may not explain the different biological behaviors of these lesions. The positive correlation observed in AOTs might be related to the formation of mineralized material in this tumor.
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Authors | Marcelo Anderson Barbosa Nascimento, Cassiano Francisco Weege Nonaka, Carlos Augusto Galvão Barboza, Roseana de Almeida Freitas, Leão Pereira Pinto, Lélia Batista de Souza |
Journal | Archives of oral biology
(Arch Oral Biol)
Vol. 73
Pg. 223-229
(Jan 2017)
ISSN: 1879-1506 [Electronic] England |
PMID | 27780042
(Publication Type: Journal Article)
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Copyright | Copyright © 2016 Elsevier Ltd. All rights reserved. |
Chemical References |
- BMP2 protein, human
- BMP4 protein, human
- Biomarkers, Tumor
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Protein 4
- BMPR2 protein, human
- Bone Morphogenetic Protein Receptors, Type I
- Bone Morphogenetic Protein Receptors, Type II
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Topics |
- Ameloblastoma
(immunology, metabolism, pathology)
- Biomarkers, Tumor
(biosynthesis)
- Bone Morphogenetic Protein 2
(biosynthesis, immunology)
- Bone Morphogenetic Protein 4
(biosynthesis, immunology)
- Bone Morphogenetic Protein Receptors, Type I
(biosynthesis, immunology)
- Bone Morphogenetic Protein Receptors, Type II
(biosynthesis, immunology)
- Cell Differentiation
(physiology)
- Endothelial Cells
(metabolism, pathology)
- Fibroblasts
(metabolism, pathology)
- Humans
- Immunohistochemistry
- Jaw Neoplasms
(immunology, metabolism, pathology)
- Parenchymal Tissue
(metabolism, pathology)
- Stromal Cells
(metabolism, pathology)
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