Abstract | BACKGROUND: Epidemiological studies reported that diabetic patients had a lower incidence of aortic dissection (AD), but the definite mechanism is unknown. We aim to investigate the possible protective effect of diabetes mellitus (DM) on AD formation with an emphasis on autonomic remodeling. METHODS: RESULTS: A total of 7 AD was noted in S + B group, DM rats did not develop AD. Diabetic rats had a lower incidence of AD (P < 0.01). In dissected aorta, collagen deposition increased while elastic fiber became fragmented. These pathological changes diminished in diabetic rats. Diabetic rats had a lower expression of ChAT (P < 0.01). URAS + BAPN treatment elevated expression of TH in normal rat and ChAT in diabetic rats (P < 0.001). Expression of MMP2 and MMP9 elevated in all the rats after URAS + BAPN, but the elevation range of MMP2 in diabetic rats was smaller (P < 0.001). CONCLUSIONS: STZ-induced diabetic rats have a lower incidence of AD after URAS and BAPN treatment, this protective effect could be possibly attributed to autonomic innervation modification and possible related down-regulation of MMP2.
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Authors | Rui Hu, Zhiwei Wang, Zongli Ren, Min Liu |
Journal | BMC cardiovascular disorders
(BMC Cardiovasc Disord)
Vol. 16
Issue 1
Pg. 200
(10 21 2016)
ISSN: 1471-2261 [Electronic] England |
PMID | 27769178
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Matrix Metalloproteinase 2
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Topics |
- Aortic Dissection
(epidemiology, metabolism, physiopathology)
- Animals
- Aortic Aneurysm, Thoracic
(epidemiology, metabolism, physiopathology)
- Autonomic Nervous System
(physiopathology)
- Blotting, Western
- Diabetes Mellitus, Experimental
(complications, metabolism, physiopathology)
- Down-Regulation
- Enzyme-Linked Immunosorbent Assay
- Incidence
- Male
- Matrix Metalloproteinase 2
(biosynthesis)
- Neuronal Plasticity
(physiology)
- Rats
- Rats, Sprague-Dawley
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