Abstract | BACKGROUND: Oligopinۚ (OP) is a quantified extract from French Maritime Pine bark (FMPB) with low molecular weight procyanidins. The cardioprotective effects of OP need to be tested in human clinical intervention trials with an appropriate design. PURPOSE: METHODS: Between February 14 and May 31, 2014, eligible subjects were recruited from the outpatient clinics of Hospital Universitari Sant Joan (Reus, Spain). A total of 24 participants (mean age ± DS; 57.36 ± 11.25; 17 men) with stage-1-hypertension who were not receiving BP-lowering medication and LDL cholesterol < 4.88 mmol/l were randomized in a double-blind, placebo-controlled, crossover study. The subjects received 2 capsules/day with 75 mg of OP or placebo for 5-weeks. RESULTS: CONCLUSION: At 5-weeks, the consumption of 150 mg/day of OP improve lipid cardiovascular profile and represents one of the scarce ways to increase HDL-c in stage-1-hypertensive subjects. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02063477.
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Authors | Rosa-M Valls, Elisabet Llauradó, Sara Fernández-Castillejo, Francesc Puiggrós, Rosa Solà, Lluis Arola, Anna Pedret |
Journal | Phytomedicine : international journal of phytotherapy and phytopharmacology
(Phytomedicine)
Vol. 23
Issue 12
Pg. 1451-1461
(Nov 15 2016)
ISSN: 1618-095X [Electronic] Germany |
PMID | 27765365
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2016. Published by Elsevier GmbH. |
Chemical References |
- Apolipoprotein A-I
- Cholesterol, HDL
- Cholesterol, LDL
- Lipids
- Lipoproteins, LDL
- Oligopin
- Plant Extracts
- Polyphenols
- Proanthocyanidins
- oxidized low density lipoprotein
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Topics |
- Aged
- Apolipoprotein A-I
(blood)
- Blood Pressure
(drug effects)
- Cardiovascular Diseases
(blood, etiology)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Cross-Over Studies
- Double-Blind Method
- Humans
- Hypertension
(blood, drug therapy)
- Lipids
(blood)
- Lipoproteins, LDL
(blood)
- Male
- Middle Aged
- Molecular Weight
- Phytotherapy
- Pinus
(chemistry)
- Plant Bark
(chemistry)
- Plant Extracts
(pharmacology, therapeutic use)
- Polyphenols
(pharmacology, therapeutic use)
- Proanthocyanidins
(pharmacology, therapeutic use)
- Risk Factors
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