Synergistic effect of anidulafungin combined with posaconazole in experimental aspergillosis.

Abstract

Clinical and experimental data have shown discrepancies on the efficacy of combinations between triazoles and echinocandins. In this study, anidulafungin plus posaconazole have shown efficacy against a murine systemic infection by three strains of Aspergillus fumigatus. The combination increased mice survival and reduced burden in the kidneys over the corresponding monotherapies and voriconazole. Clearance of kidneys was observed in 62% to 100% of animals (strain dependant). We observed good in vitro- in vivo correlation when a cutoff < 1 was indicative of synergy. Our results showed that the combination could be a therapeutical option, especially against infections refractory to the first line therapy.

• Authors: Adela Martin-Vicente, Javier Capilla, Josep Guarro
• Journal: Medical mycology (Med Mycol) Vol. 55 Issue 4 Pg. 457-460 (Jun 01 2017) ISSN: 1460-2709 [Electronic] England
• PMID: 27760829 (Publication Type: Journal Article)
• Copyright: © The Author 2016. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: [email protected].

Chemical References

• Antifungal Agents
• Echinocandins
• Triazoles
• posaconazole
• Anidulafungin

Topics

• Anidulafungin
• Animals
• Antifungal Agents (administration & dosage, pharmacology)
• Aspergillosis (drug therapy)
• Aspergillus fumigatus (drug effects, isolation & purification)
• Disease Models, Animal
• Drug Synergism
• Drug Therapy, Combination
• Echinocandins (administration & dosage, pharmacology)
• Kidney (microbiology)
• Male
• Mice
• Survival Analysis
• Triazoles (administration & dosage, pharmacology)