PROGNOSTIC FACTORS AND SURVIVAL ANALYSIS IN ESOPHAGEAL CARCINOMA.

Abstract

BACKGROUND:

Despite recent advances in diagnosis and treatment, esophageal cancer still has high mortality. Prognostic factors associated with patient and with disease itself are multiple and poorly explored.

AIM:

Assess prognostic variables in esophageal cancer patients.

METHODS:

Retrospective review of all patients with esophageal cancer in an oncology referral center. They were divided according to histological diagnosis (444 squamous cell carcinoma patients and 105 adenocarcinoma), and their demographic, pathological and clinical characteristics were analyzed and compared to clinical stage and overall survival.

RESULTS:

No difference was noted between squamous cell carcinoma and esophageal adenocarcinoma overall survival curves. Squamous cell carcinoma presented 22.8% survival after five years against 20.2% for adenocarcinoma. When considering only patients treated with curative intent resection, after five years squamous cell carcinoma survival rate was 56.6 and adenocarcinoma, 58%. In patients with squamous cell carcinoma, poor differentiation histology and tumor size were associated with worse oncology stage, but this was not evidenced in adenocarcinoma.

CONCLUSION:

Weight loss (kg), BMI variation (kg/m²) and percentage of weight loss are factors that predict worse stage at diagnosis in the squamous cell carcinoma. In adenocarcinoma, these findings were not statistically significant.

• Authors: Francisco Tustumi, Cintia Mayumi Sakurai Kimura, Flavio Roberto Takeda, Rodrigo Hideki Uema, Rubens Antônio Aissar Salum, Ulysses Ribeiro-Junior, Ivan Cecconello
• Journal: Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery (Arq Bras Cir Dig) Vol. 29 Issue 3 Pg. 138-141 ( 2016) ISSN: 2317-6326 [Electronic] Brazil
• PMID: 27759773 (Publication Type: Journal Article)

Topics

• Adenocarcinoma (mortality)
• Carcinoma, Squamous Cell (mortality)
• Esophageal Neoplasms (mortality)
• Female
• Humans
• Male
• Middle Aged
• Prognosis
• Retrospective Studies
• Survival Analysis
• Survival Rate