Abstract | BACKGROUND & AIMS: METHODS: We prospectively evaluated whether liver fat predicted the development of CVD risk factors and whether CVD risk factors predicted new onset fatty liver during 6years of follow-up in middle- to older-aged Framingham Heart Study participants. We estimated liver fat using multi-detector computed tomography. RESULTS: We included 1051 participants (mean age 45±6years, 46% women). The prevalence of fatty liver was 18% at baseline. In participants without fatty liver at baseline, 101 participants developed incident fatty liver over approximately 6years. Baseline liver fat (per standard deviation increase) was associated with increased odds of incident hypertension (OR 1.42; 95% CI 1.15-1.76; p=0.001) and incident type 2 diabetes (OR 1.43; 95% CI 1.09-1.88, p<0.001). In a parallel analysis, individuals with hypertension (OR 3.34; 95% CI 2.04-5.49), hypertriglyceridemia (OR 3.04; 95% CI: 1.84-5.02), impaired fasting glucose (OR 2.92; 95% CI 1.76-4.82), or type 2 diabetes (OR 4.15; 95% CI 1.19-14.46) at baseline had higher odds of incident fatty liver compared to individuals without those conditions (all p<0.03). In both analyses, the observed associations remained similar after additional adjustments for measures of adiposity. CONCLUSIONS: The present study demonstrated bi-directional relationships between fatty liver and CVD risk factors among middle- to older-aged Framingham Heart Study participants. LAY SUMMARY:
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Authors | Jiantao Ma, Shih-Jen Hwang, Alison Pedley, Joseph M Massaro, Udo Hoffmann, Raymond T Chung, Emelia J Benjamin, Daniel Levy, Caroline S Fox, Michelle T Long |
Journal | Journal of hepatology
(J Hepatol)
Vol. 66
Issue 2
Pg. 390-397
(02 2017)
ISSN: 1600-0641 [Electronic] Netherlands |
PMID | 27729222
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2016 European Association for the Study of the Liver. All rights reserved. |
Topics |
- Adiposity
- Adult
- Cardiovascular Diseases
(epidemiology)
- Female
- Humans
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
(epidemiology)
- Prevalence
- Risk Factors
- United States
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