In-vitro activity of solithromycin against anaerobic bacteria from the normal intestinal microbiota.

Abstract	Solithromycin is a novel fluoroketolide with high activity against bacteria associated with community-acquired respiratory tract infections as well as gonorrhea. However, data on the activity of solithromycin against anaerobic bacteria from the normal intestinal microbiota are scarce. In this study, 1024 Gram-positive and Gram-negative anaerobic isolates from the normal intestinal microbiota were analyzed for in-vitro susceptibility against solithromycin and compared to azithromycin, amoxicillin/clavulanic acid, ceftriaxone, metronidazole and levofloxacin by determining the minimum inhibitory concentration (MIC). Solithromycin was active against Bifidobacteria (MIC50, 0.008 mg/L) and Lactobacilli (MIC50, 0.008 mg/L). The MIC50 for Clostridia, Bacteroides, Prevotella and Veillonella were 0.5, 0.5, 0.125 and 0.016 mg/L, respectively. Gram-positive anaerobes were more susceptible to solithromycin as compared to the other antimicrobials tested. The activity of solithromycin against Gram-negative anaerobes was equal or higher as compared to other tested agents.
Authors	Andrej Weintraub, Mamun-Ur Rashid, Carl Erik Nord
Journal	Anaerobe (Anaerobe) Vol. 42 Pg. 119-122 (Dec 2016) ISSN: 1095-8274 [Electronic] England
PMID	27725229 (Publication Type: Journal Article)
Copyright	Copyright Â© 2016 Elsevier Ltd. All rights reserved.
Chemical References	Anti-Bacterial Agents Macrolides Triazoles Metronidazole Levofloxacin Amoxicillin-Potassium Clavulanate Combination Ceftriaxone Azithromycin solithromycin
Topics	Amoxicillin-Potassium Clavulanate Combination (pharmacology) Anaerobiosis Anti-Bacterial Agents (pharmacology) Azithromycin (pharmacology) Bacteria, Anaerobic Ceftriaxone (pharmacology) Gastrointestinal Microbiome (drug effects, physiology) Gastrointestinal Tract (microbiology) Gram-Negative Anaerobic Bacteria (drug effects, growth & development) Gram-Positive Bacteria (drug effects, growth & development) Humans Levofloxacin (pharmacology) Macrolides (pharmacology) Metronidazole (pharmacology) Microbial Sensitivity Tests Species Specificity Triazoles (pharmacology)

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