Tumour-Targeted Drug Delivery with Mannose-Functionalized Nanoparticles Self-Assembled from Amphiphilic β-Cyclodextrins.

Abstract

Multivalent mannose-functionalized nanoparticles self-assembled from amphiphilic β-cyclodextrins (β-CDs) facilitate the targeted delivery of anticancer drugs to specific cancer cells. Doxorubicin (DOX)-loaded nanoparticles equipped with multivalent mannose target units were efficiently taken up via receptor-mediated endocytosis by MDA-MB-231 breast cancer cells that overexpress the mannose receptor. Upon entering the cell, the intracellular pH causes the release of DOX, which triggers apoptosis. Targeting by multivalent mannose significantly improved the capability of DOX-loaded nanoparticles to inhibit the growth of MDA-MB-231 cancer cells with minimal side effects in vivo. This targeted and controlled drug delivery system holds promise as a nanotherapeutic for cancer treatment.

• Authors: Zhou Ye, Quan Zhang, Shengtao Wang, Priya Bharate, Silvia Varela-Aramburu, Mengji Lu, Peter H Seeberger, Jian Yin
• Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (Chemistry) Vol. 22 Issue 43 Pg. 15216-15221 (Oct 17 2016) ISSN: 1521-3765 [Electronic] Germany
• PMID: 27714939 (Publication Type: Journal Article)
• Copyright: © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Antineoplastic Agents
• Lectins, C-Type
• Mannose Receptor
• Mannose-Binding Lectins
• Receptors, Cell Surface
• beta-Cyclodextrins
• Doxorubicin
• Mannose

Topics

• Antineoplastic Agents (administration & dosage, chemistry, pharmacology)
• Breast Neoplasms (drug therapy)
• Cell Line, Tumor
• Doxorubicin (administration & dosage, chemistry, pharmacology)
• Drug Delivery Systems
• Female
• Humans
• Lectins, C-Type
• Mannose (chemistry, pharmacology)
• Mannose Receptor
• Mannose-Binding Lectins
• Nanoparticles
• Receptors, Cell Surface
• beta-Cyclodextrins (pharmacology)