Redox/pH dual stimuli-responsive degradable Salecan-g-SS-poly(IA-co-HEMA) hydrogel for release of doxorubicin.

Abstract

Salecan is a novel water-soluble extracellular β-glucan and possesses excellent physicochemical and biological properties. Here, redox/pH dual stimuli-responsive hydrogel based on Salecan grafted with itaconic acid (IA) and 2-hydroxyethyl methacrylate (HEMA) were prepared using disulfide-functionalized crosslinker N,N-bis(acryloyl)cystamine (BAC) for controlled drug delivery. The introduction of carboxylic groups endows the system with pH-sensitive character, swelling behavior of the hydrogel was conducted by changing the pH and Salecan content. It was demonstrated that DOX was efficiently loaded into the hydrogels and released in a controlled fashion via pH-control and swelling-shrinking mechanism. More importantly, DOX-loaded hydrogels showed dose dependent cytotoxicity toward A549 cell, and efficient cell killing was observed. Furthermore, a key point of this study was that the presence of disulfide linkage in system favored the degradation of hydrogels in the reductive environment. These results highlight the potential of Salecan-g-SS-poly(IA-co-HEMA) hydrogel as a novel system for the controlled release of anti-cancer drugs.

• Authors: Xinyu Hu, Yongmei Wang, Liangliang Zhang, Man Xu, Wei Dong, Jianfa Zhang
• Journal: Carbohydrate polymers (Carbohydr Polym) Vol. 155 Pg. 242-251 (Jan 02 2017) ISSN: 1879-1344 [Electronic] England
• PMID: 27702509 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Hydrogels
• Methacrylates
• beta-Glucans
• salecan
• hydroxyethyl methacrylate
• Doxorubicin

Topics

• Antineoplastic Agents (chemistry)
• Doxorubicin (chemistry)
• Drug Delivery Systems
• Hydrogels
• Hydrogen-Ion Concentration
• Methacrylates (chemistry)
• Oxidation-Reduction
• beta-Glucans (chemistry)