The Predictive Value of Tumor Size, Volume, and Markers During Radiation Therapy in Patients With Cervical Cancer.

Abstract

OBJECTIVES:

We investigated the prognostic significance of changes in primary tumor volume and serum squamous cell carcinoma antigen (SCC-ag) levels during radiation therapy (RT) in patients with cervical cancer.

METHODS:

We conducted a review of 40 patients treated with RT. All patients received external beam RT and intracavitary brachytherapy. The primary tumor volume and squamous cell carcinoma antigen levels were measured pre-RT and mid-RT. Overall survival (OS) and progression free survival (PFS) were estimated, and possible prognostic factors for survival were analyzed.

RESULTS:

The correlation coefficient between primary tumor volume reduction rate (pTVRR) and serum squamous cell carcinoma antigen reduction rate in all patients was 0.550 (P < 0.001). In univariate analysis, stage more than II (P <0.001), pre-RT pTV of 55 cm or more (P = 0.05), mid-RT tumor size of 4 cm or more (P = 0.004), and pTVRR of 90% or less (P = 0.031) were significant unfavorable prognostic factors for PFS, whereas stage (P = 0.009) was the only significant prognostic factor for OS. Multivariable analysis revealed that none of these factors were independently associated with PFS or OS.

CONCLUSIONS:

There was a significant correlation between pTVRR and squamous cell carcinoma antigen reduction rate. Our findings indicate that the tumor parameters such as pre-RT pTV, mid-RT tumor size, and pTVRR are associated with PFS in women with cervical cancer.

• Authors: Kyu Chan Lee, Hun Jung Kim, KiHoon Sung, Young Eun Choi, Seok Ho Lee, Soyi Lim, Kwang Beom Lee, Jin Woo Shin, Chan Yong Park, Young Saing Kim, Sun Jin Sym, Young Sup Shim, Seung Joon Choi
• Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (Int J Gynecol Cancer) Vol. 27 Issue 1 Pg. 123-130 (01 2017) ISSN: 1525-1438 [Electronic] England
• PMID: 27668394 (Publication Type: Journal Article)

Chemical References

• Antigens, Neoplasm
• Biomarkers, Tumor
• Serpins
• squamous cell carcinoma-related antigen

Topics

• Adult
• Aged
• Aged, 80 and over
• Antigens, Neoplasm (blood)
• Biomarkers, Tumor (blood)
• Brachytherapy
• Disease-Free Survival
• Female
• Humans
• Middle Aged
• Neoplasm Staging
• Predictive Value of Tests
• Prognosis
• Retrospective Studies
• Serpins (blood)
• Survival Rate
• Uterine Cervical Neoplasms (blood, diagnosis, pathology, radiotherapy)