Abstract | BACKGROUND: OBJECTIVE: To test the hypothesis that M1 receptor uncoupling is correlated with Aβ burden, we aimed to study muscarinic M1 neurochemical parameters in neurodegenerative dementias characterized by low and high Aβ loads. METHODS: RESULTS: We found unchanged levels of M1 receptors in both dementia groups, while M1 coupling was reduced only in AD + CVD (p < 0.01). Furthermore, Aβ concentration was significantly increased only in AD + CVD, and correlated negatively with M1-G-protein coupling in the dementia groups. CONCLUSIONS: Our study suggests that loss of M1 coupling to G-proteins may be a neurochemical feature of neurodegenerative dementias with high cortical Aβ burden, and that cholinergic replacement therapies may be more efficacious for PDD due to low Aβ burden.
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Authors | Jasinda H Lee, Paul T Francis, Clive G Ballard, Dag Aarsland, Raj N Kalaria, Peter T-H Wong, Christopher P Chen, Mitchell K P Lai |
Journal | Journal of Parkinson's disease
(J Parkinsons Dis)
Vol. 6
Issue 4
Pg. 733-739
(10 19 2016)
ISSN: 1877-718X [Electronic] Netherlands |
PMID | 27662332
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptor, Muscarinic M1
- GTP-Binding Proteins
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Topics |
- Aged
- Aged, 80 and over
- Alzheimer Disease
(metabolism, pathology)
- Dementia
(metabolism, pathology)
- Dementia, Vascular
(metabolism, pathology)
- Female
- Frontal Lobe
(metabolism, pathology)
- GTP-Binding Proteins
(metabolism)
- Humans
- Longitudinal Studies
- Male
- Parkinson Disease
(metabolism, pathology)
- Receptor, Muscarinic M1
(metabolism)
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