Abstract | BACKGROUND: METHODS: We quantified the levels of total vitamin D [25-( OH) D2 and D3] in serum samples from 400 HBV patients ( chronic hepatitis B infection [CHB], n = 165; HBV-associated liver cirrhosis [LC], n = 127; HBV-associated hepatocellular carcinoma [HCC], n = 108) and 122 unrelated healthy controls (HC). Univariate and multivariate analyses were performed in order to determine the association between vitamin D levels and distinct clinical parameters. RESULTS: The prevalence of vitamin D inadequacy (<30 ng/mL) was high among healthy individuals (81.7 %) as well as in HBV patients (84.3 %). Vitamin D deficiency (<20 ng/ml) or severe deficiency (<10 ng/ml) was observed more frequently among HBV patients (52 %) and subgroups (CHB, 47.8 %; LC, 54.4 %; HCC, 55.3 %) compared to the control group (32.5 %) (P < 0.001). Vitamin D levels and HBV- DNA load were strongly and inversely correlated (rho = -0.57, P < 0.0001). Multivariate regression analysis also revealed an independent association of HBV- DNA loads with low vitamin D levels (P = 0.0004). In addition, reduced vitamin D levels were associated with significant clinical progression of LC (Child-Pugh C versus Child-Pugh A, P = 0.0018; Child-Pugh C versus Child-Pugh B, P = 0.016). CONCLUSIONS:
Vitamin D deficiency was observed in the majority of HBV-infected patients and associated with adverse clinical outcomes. Our findings suggest that substitution of vitamin D may be a supportive option in the treatment of chronic liver diseases, in particular of HBV-associated disorders.
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Authors | Nghiem Xuan Hoan, Nguyen Khuyen, Mai Thanh Binh, Dao Phuong Giang, Hoang Van Tong, Phan Quoc Hoan, Ngo Tat Trung, Do Tuan Anh, Nguyen Linh Toan, Christian G Meyer, Peter G Kremsner, Thirumalaisamy P Velavan, Le Huu Song |
Journal | BMC infectious diseases
(BMC Infect Dis)
Vol. 16
Issue 1
Pg. 507
(Sep 23 2016)
ISSN: 1471-2334 [Electronic] England |
PMID | 27659316
(Publication Type: Journal Article)
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