Abstract | INTRODUCTION: METHODS: Sprague-Dawley rats were subjected to polytrauma ( laparotomy, and trauma to intestines, liver, right leg skeletal muscle, and right femur fracture), then bled 40% of their blood volume. One hour after completion of polytrauma and hemorrhage, resuscitation was begun with fresh whole blood (FWB) or FWB with prior bolus administration of TXA (10 mg/kg in 0.2 mL). RESULTS: CONCLUSION:
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Authors | Xiaowu Wu, Michael A Dubick, Martin G Schwacha, Andrew P Cap, Daniel N Darlington |
Journal | Shock (Augusta, Ga.)
(Shock)
Vol. 47
Issue 4
Pg. 500-505
(04 2017)
ISSN: 1540-0514 [Electronic] United States |
PMID | 27648695
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
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Topics |
- Acute Lung Injury
(drug therapy, metabolism)
- Animals
- Disease Models, Animal
- Hemorrhage
(drug therapy, metabolism)
- Lung
(drug effects, metabolism)
- Male
- Multiple Trauma
(drug therapy, metabolism)
- Rats
- Rats, Sprague-Dawley
- Resuscitation
(methods)
- Tranexamic Acid
(therapeutic use)
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