IL-17A attracts inflammatory cells in murine lung infection with P. aeruginosa.

Abstract

IL-17A-dependent immunity is of importance in the protection against extracellular bacterial pathogens. However, IL-17A is also suggested to mediate the pathogenesis of lung diseases, such as acute respiratory distress syndrome. Here, we studied the role of IL-17A in a mouse model of acute pneumonia. IL-17A mediated the expression of keratinocyte-derived chemokine (KC) and the recruitment of inflammatory cells in mice infected with a sub-lethal dose of Pseudomonas aeruginosa. IL-17A deficiency protected mice from lethal P. aeruginosa lung infection. A sub-lethal infection with Streptococcus pneumoniae resulted in increased bacterial burden associated with increased pulmonary inflammation. Thus, the type of infectious bacteria seemed to influence the way in which IL-17A functions during pulmonary infection. Reducing pulmonary inflammation by targeting IL-17A may be a therapeutic option in acute P. aeruginosa pneumonia.

• Authors: Bodo Wonnenberg, Christopher Jungnickel, Anja Honecker, Lisa Wolf, Meike Voss, Markus Bischoff, Thomas Tschernig, Christian Herr, Robert Bals, Christoph Beisswenger
• Journal: Innate immunity (Innate Immun) Vol. 22 Issue 8 Pg. 620-625 (11 2016) ISSN: 1753-4267 [Electronic] United States
• PMID: 27634821 (Publication Type: Journal Article)

Chemical References

• Interleukin-17

Topics

• Animals
• Cell Movement
• Cells, Cultured
• Humans
• Immunity (genetics)
• Interleukin-17 (genetics, metabolism)
• Keratinocytes (immunology)
• Mice
• Mice, Inbred C57BL
• Mice, Knockout
• Molecular Targeted Therapy
• Pneumococcal Infections (immunology, therapy)
• Pneumonia (immunology)
• Pseudomonas Infections (immunology, therapy)
• Pseudomonas aeruginosa (immunology)
• Respiratory Distress Syndrome (immunology, therapy)
• Species Specificity
• Streptococcus pneumoniae (immunology)