Abstract | BACKGROUND: Long non-coding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. However, the role and molecular mechanism of lncRNA XIST in gastric cancer is still unknown. METHODS: Real-time PCR analysis was performed to measure the expression levels of lncRNA XIST in gastric cancer tissues and cell lines, the correlation between lncRNA XIST expression and clinicopathological characteristics and prognosis was analyzed in gastric cancer patients. The biological function of lncRNA XIST on gastric cancer cells were determined both in vitro and in vivo. The regulating relationship between lncRNA XIST and miR-101 was investigated in gastric cancer cells. RESULTS: CONCLUSIONS:
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Authors | Dong-Liang Chen, Huai-Qiang Ju, Yun-Xin Lu, Le-Zong Chen, Zhao-Lei Zeng, Dong-Sheng Zhang, Hui-Yan Luo, Feng Wang, Miao-Zhen Qiu, De-Shen Wang, Da-Zhi Xu, Zhi-Wei Zhou, Helene Pelicano, Peng Huang, Dan Xie, Feng-Hua Wang, Yu-Hong Li, Rui-Hua Xu |
Journal | Journal of experimental & clinical cancer research : CR
(J Exp Clin Cancer Res)
Vol. 35
Issue 1
Pg. 142
(09 13 2016)
ISSN: 1756-9966 [Electronic] England |
PMID | 27620004
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- MIRN101 microRNA, human
- MicroRNAs
- RNA, Long Noncoding
- XIST non-coding RNA
- EZH2 protein, human
- Enhancer of Zeste Homolog 2 Protein
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Topics |
- Animals
- Cell Line, Tumor
- Disease Progression
- Enhancer of Zeste Homolog 2 Protein
(genetics)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Male
- MicroRNAs
(genetics)
- Neoplasm Metastasis
- Neoplasm Staging
- Neoplasm Transplantation
- Prognosis
- RNA, Long Noncoding
(genetics)
- Stomach Neoplasms
(genetics, pathology)
- Survival Analysis
- Tumor Burden
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