Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes.

Abstract

AIMS:

To assess associations between body mass index (BMI), waist circumference (WC), and computed tomography-determined volumes of pericardial, visceral, and subcutaneous adipose tissue with magnetic resonance imaging-(MRI) based cerebral structure and cognitive performance in individuals with type 2 diabetes (T2D).

METHODS:

This study was performed in 348 African Americans (AAs) and 256 European Americans (EAs) with T2D. Associations between adiposity measures with cerebral volumes of white matter (WMV), gray matter (GMV), white matter lesions, hippocampal GMV, and hippocampal WMV, cognitive performance and depression were examined using marginal models incorporating generalized estimating equations. All models were adjusted for age, sex, education, smoking, HbA1c, hypertension, statins, cardiovascular disease, MRI scanner (MRI outcomes only), and time between scans; some neuroimaging measures were additionally adjusted for intracranial volume.

RESULTS:

Participants were 59.9% female with mean (SD) age 57.7(9.3)years, diabetes duration 9.6(6.8)years, and HbA1c 7.8(1.9)%. In AAs, inverse associations were detected between hippocampal GMV and both BMI (β [95% CI]-0.18 [-0.30, -0.07], P=0.0018) and WC (-0.23 [-0.35, -0.12], P=0.0001). In the full bi-ethnic sample, inverse associations were detected between hippocampal WMV and WC (P≤0.0001). Positive relationships were observed between BMI (P=0.0007) and WC (P<0.0001) with depression in EAs.

CONCLUSIONS:

In patients with T2D, adiposity is inversely associated with hippocampal gray and white matter volumes.

• Authors: Fang-Chi Hsu, Mingxia Yuan, Donald W Bowden, Jianzhao Xu, S Carrie Smith, Lynne E Wagenknecht, Carl D Langefeld, Jasmin Divers, Thomas C Register, J Jeffrey Carr, Jeff D Williamson, Kaycee M Sink, Joseph A Maldjian, Barry I Freedman
• Journal: Journal of diabetes and its complications (J Diabetes Complications) 2016 Nov - Dec Vol. 30 Issue 8 Pg. 1506-1512 ISSN: 1873-460X [Electronic] United States
• PMID: 27615667 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Topics

• Adipose Tissue (diagnostic imaging)
• Adiposity
• Black or African American
• Aged
• Body Mass Index
• Diabetes Mellitus, Type 2 (physiopathology)
• Female
• Gray Matter (diagnostic imaging)
• Hippocampus (anatomy & histology, diagnostic imaging)
• Humans
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Organ Size
• Tomography, X-Ray Computed
• United States
• Waist Circumference
• White Matter (diagnostic imaging)
• White People