Relationship between interleukin-1β and depressive disorder after acute coronary syndrome.

Abstract

This study was aimed to investigate the effect of serum interleukin (IL)-1β in the depression trajectory after acute coronary syndrome (ACS) considering two IL-1β polymorphisms: -511C/T or +3953C/T. A total of 969 patients were evaluated within 2weeks after ACS and of these, 711 were followed-up 1year later. Depressive disorders were evaluated at baseline and 1year after ACS, using the Mini-International Neuropsychiatric Interview. Serum IL-1β levels and IL-1β genotypes were investigated at baseline. Covariates on socio-demographic and clinical characteristics including depressive symptoms, cardiovascular risk factors, and current cardiac status were assessed. Depression during the acute ACS was significantly associated with the IL-1β levels and the -511T allele. The interaction of the IL-1β level with depression at baseline in the presence of the -511T allele was also significant. No associations were found with depression during the chronic ACS. For the +3953C/T genotype, there was no association with depression in either the acute or chronic phase. The IL-1β level and -511C/T genotype, separately or interactively, could be a biomarker for depressive disorder in the acute phase of ACS. Focused interventions for those with higher IL-1β level and -511T allele might reduce the risk of depressive disorder.

• Authors: Hee-Ju Kang, Kyung-Yeol Bae, Sung-Wan Kim, Il-Seon Shin, Young Joon Hong, Youngkeun Ahn, Myung Ho Jeong, Jin-Sang Yoon, Jae-Min Kim
• Journal: Progress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry) Vol. 72 Pg. 55-59 (01 04 2017) ISSN: 1878-4216 [Electronic] England
• PMID: 27608541 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Chemical References

• Interleukin-1beta

Topics

• Acute Coronary Syndrome (complications, genetics)
• Chi-Square Distribution
• Depressive Disorder (blood, etiology)
• Female
• Follow-Up Studies
• Genotype
• Humans
• Interleukin-1beta (blood, genetics)
• Male
• Polymorphism, Single Nucleotide (genetics)
• Risk Factors