Abstract | OBJECTIVE: The pathogenesis of immune dysfunction in chronic HIV-1 infection is unclear, and a potential role for oxidized lipids has been suggested. We hypothesize that both oxidized HDL and LDL (HDLox and LDLox) contribute to HIV-1-related immune dysfunction. STUDY: METHODS: RESULTS: HDLox declined and LDLox increased over 96 weeks of ART. Positive associations were observed at baseline and over time between HDLox (but not consistently for LDLox) and most markers of inflammation and immune activation (but not senescence/exhaustion), even after adjustment for multiple comparisons, demographics, entry CD4 cell count and HIV-1 RNA. HDLox was positively associated with IL-6 (r = 0.19 - 0.29, P < 0.01) and sCD163 (r = 0.14 - 0.41, P ≤ 0.04) at all time points. CONCLUSION: These prospective longitudinal data suggest that oxidized lipoproteins may contribute to persistent immune activation on ART.
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Authors | Theodoros Kelesidis, Nicholas Jackson, Grace A McComsey, Xiaoyan Wang, David Elashoff, Michael P Dube, Todd T Brown, Otto O Yang, James H Stein, Judith S Currier |
Journal | AIDS (London, England)
(AIDS)
Vol. 30
Issue 17
Pg. 2625-2633
(11 13 2016)
ISSN: 1473-5571 [Electronic] England |
PMID | 27603288
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
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Chemical References |
- Anti-HIV Agents
- Antigens, CD
- Fibrin Fibrinogen Degradation Products
- IL6 protein, human
- Interleukin-6
- Lipoproteins
- fibrin fragment D
- C-Reactive Protein
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Topics |
- Adult
- Anti-HIV Agents
(therapeutic use)
- Antigens, CD
(analysis)
- Antiretroviral Therapy, Highly Active
(methods)
- C-Reactive Protein
(analysis)
- Female
- Fibrin Fibrinogen Degradation Products
(analysis)
- HIV Infections
(drug therapy, pathology)
- Humans
- Inflammation
(pathology)
- Interleukin-6
(blood)
- Lipoproteins
(analysis, chemistry)
- Longitudinal Studies
- Male
- Monocytes
(chemistry, immunology)
- Oxidation-Reduction
- Prospective Studies
- Sustained Virologic Response
- T-Lymphocytes
(chemistry, immunology)
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