Disposition of a long-acting oxytetracycline formulation in Thai swamp buffaloes (Bubalus bubalis).

Abstract

The present study aimed to characterize the pharmacokinetic profile of oxytetracycline long-acting formulation (OTC-LA) in Thai swamp buffaloes, Bubalus bubalis, following single intramuscular administration at two dosages of 20 and 30 mg/kg body weight (b.w.). Blood samples were collected at assigned times up to 504 h. The plasma concentrations of OTC were measured by high-performance liquid chromatography (HPLC). The concentrations of OTC in the plasma were determined up to 264 h and 432 h after i.m. administration at doses of 20 and 30 mg/kg b.w., respectively. The Cmax values of OTC were 12.11 ± 1.87 μg/mL and 12.27 ± 1.92 μg/mL at doses of 20 and 30 mg/kg, respectively. The AUClast values increased in a dose-dependent fashion. The half-life values were 52.00 ± 14.26 h and 66.80 ± 10.91 h at doses of 20 and 30 mg/kg b.w, respectively. Based on the pharmacokinetic data and PK-PD index (T > MIC), i.m. administration of OTC at a dose of 30 mg/kg b.w once per week might be appropriate for the treatment of susceptible bacterial infection in Thai swamp buffaloes.

• Authors: S Poapolathep, K Wongpanit, K Imsilp, P Tanhan, N Klangkaew, M Giorgi, A Poapolathep
• Journal: Journal of veterinary pharmacology and therapeutics (J Vet Pharmacol Ther) Vol. 40 Issue 2 Pg. 206-209 (Apr 2017) ISSN: 1365-2885 [Electronic] England
• PMID: 27597645 (Publication Type: Clinical Trial, Journal Article)
• Copyright: © 2016 John Wiley & Sons Ltd.

Chemical References

• Anti-Bacterial Agents
• Delayed-Action Preparations
• Oxytetracycline

Topics

• Animals
• Anti-Bacterial Agents (administration & dosage, blood, pharmacokinetics)
• Area Under Curve
• Buffaloes (blood)
• Delayed-Action Preparations
• Female
• Half-Life
• Oxytetracycline (administration & dosage, blood, pharmacokinetics)