Abstract |
Al(3+), Fe(3+), and Zn(2+) ions can disturb microtubule assembly from tubulin and microtubuleassociated proteins in rat brain. The main structural forms of these microtubules are rings and tangled bundles. These structures are formed only in the presence of Al(3+) and Fe(3+) ions. Therefore, Zn(2+) ions can be excluded from possible causes of structural abnormalities in microtubules during Alzheimer's disease. Al(3+) ions are the most probable etiological cause of Alzheimer's disease. The concentration of Al(3+) ions affecting the structure of microtubules is one order of magnitude lower than that of Fe(3+) ions (10 and 100 μM, respectively), which corresponds to their brain concentration reported in Alzheimer's disease.
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Authors | P N Shevtsov, E F Shevtsova, G Sh Burbaeva |
Journal | Bulletin of experimental biology and medicine
(Bull Exp Biol Med)
Vol. 161
Issue 4
Pg. 451-5
(Aug 2016)
ISSN: 1573-8221 [Electronic] United States |
PMID | 27591874
(Publication Type: Journal Article)
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Chemical References |
- Microtubule Proteins
- Aluminum
- Iron
- Zinc
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Topics |
- Aluminum
(pharmacology)
- Animals
- Brain
(drug effects, metabolism, ultrastructure)
- Cognition
(drug effects)
- Iron
(pharmacology)
- Memory
(drug effects)
- Microtubule Proteins
(drug effects, metabolism, ultrastructure)
- Microtubules
(drug effects, metabolism, ultrastructure)
- Rats
- Zinc
(pharmacology)
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