Poly(styrenesulfonate)-Modified Ni-Ti Layered Double Hydroxide Film: A Smart Drug-Eluting Platform.

Abstract

Drug-eluting stents (DESs) are widely used in the palliative treatment of many kinds of cancers. However, the covered polymers used in DESs are usually associated with stent migration and acute cholecystitis. Therefore, developing noncovered drug-loading layers on metal stents is of great importance. In this work, Ni-Ti layered double hydroxide (Ni-Ti LDH) films were prepared on the surface of nitinol via hydrothermal treatment, and the LDH films were further modified by poly(styrenesulfonate) (PSS). The anticancer drug doxorubicin could be effectively loaded onto the modified films, and drug release could be smartly controlled by the pH. Besides, the drug absorption amounts of cancer cells cultured on the films could be effectively improved. These results indicate that the PSS-modified LDH film may become a promising drug-loading platform that can be used in the design of DESs.

• Authors: Naijian Ge, Donghui Wang, Feng Peng, Jinhua Li, Yuqin Qiao, Xuanyong Liu
• Journal: ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 8 Issue 37 Pg. 24491-501 (Sep 21 2016) ISSN: 1944-8252 [Electronic] United States
• PMID: 27579782 (Publication Type: Journal Article)

Chemical References

• Hydroxides
• Polystyrenes
• titanium nickelide
• polystyrene sulfonic acid
• Nickel
• Titanium

Topics

• Drug Liberation
• Drug-Eluting Stents
• Hydroxides
• Nickel
• Polystyrenes (chemistry)
• Titanium