Abstract | BACKGROUND: METHODS: To investigate whether naturally acquired anti-PvDBP antibodies are associated with reduced risk of clinical malaria in a population exposed to low levels of P. vivax transmission, we measured total levels of immunoglobulin G antibodies to 5 PvDBP variants and used a functional in vitro assay to quantify their binding-inhibitory activity in a cohort of 466 rural Amazonians followed up for up to 37 months. RESULTS: No association between total immunoglobulin G antibody responses to any PvDBP variant and risk of symptomatic, laboratory-confirmed vivax malaria was observed in this cohort. However, a Cox proportional hazards model, adjusted for age, sex, and genotype for the Duffy antigen/receptor for chemokines, showed a >40% decrease in the prospective risk of clinical vivax malaria in subjects with the strongest BIAb responses (upper and middle terciles). High BIAb responses were mostly PvDBP variant transcending and stable over time. CONCLUSIONS: Strong naturally acquired BIAb responses are associated with a reduced risk of clinical P. vivax malaria in rural Amazonians.
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Authors | Vanessa C Nicolete, Sarah Frischmann, Susana Barbosa, Christopher L King, Marcelo U Ferreira |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 214
Issue 10
Pg. 1539-1546
(11 15 2016)
ISSN: 1537-6613 [Electronic] United States |
PMID | 27578850
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail [email protected]. |
Chemical References |
- Antibodies, Protozoan
- Antigens, Protozoan
- Duffy antigen binding protein, Plasmodium
- Immunoglobulin G
- Protozoan Proteins
- Receptors, Cell Surface
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Protozoan
(blood)
- Antigens, Protozoan
(immunology)
- Brazil
- Child
- Child, Preschool
- Cross-Sectional Studies
- Female
- Humans
- Immunoglobulin G
(blood)
- Infant
- Malaria, Vivax
(immunology, prevention & control)
- Male
- Middle Aged
- Plasmodium vivax
(immunology)
- Prospective Studies
- Protozoan Proteins
(immunology)
- Receptors, Cell Surface
(immunology)
- Rural Population
- Young Adult
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