Detection of prostate cancer local recurrence following radical prostatectomy: assessment using a continuously acquired radial golden-angle compressed sensing acquisition.

Abstract

PURPOSE:

To compare image quality and diagnostic performance for detecting local recurrence (LR) of prostate cancer after radical prostatectomy (RP) between standard dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and a high spatiotemporal resolution, continuously acquired Golden-angle RAdial Sparse Parallel acquisition employing compressed sensing reconstruction ("GRASP").

METHODS:

A search was conducted for prostate MRI examinations performed in patients with PSA ≥0.2 ng/mL after RP in whom follow-up evaluation allowed classification as positive (≥50% PSA reduction after pelvic radiation or positive biopsy) or negative (<50% PSA reduction after pelvic radiation; spontaneous PSA normalization) for LR, yielding 13 patients with standard DCE (11 LR+) and 12 with GRASP (10 LR+). Standard DCE had voxel size 3.0 × 1.9 × 1.9 mm and temporal resolution 5.5 s. GRASP had voxel size 1.0 × 1.1 × 1.1 cm and was retrospectively reconstructed at 2.3 s resolution. Two radiologists evaluated DCE sequences for image quality measures (1-5 scale) and the presence of LR.

RESULTS:

GRASP achieved higher scores than standard DCE from both readers (p < 0.001-0.136) for anatomic clarity (R1: 4.4 ± 0.8 vs. 2.8 ± 0.67 R2: 4.8 ± 0.5 vs. 3.2 ± 0.6), sharpness (3.6 ± 0.9 vs. 2.5 ± 0.7; 4.6 ± 0.5 vs. 2.6 ± 0.5), confidence in interpretation (3.8 ± 0.8 vs. 3.1 ± 0.9; 3.8 ± 1.0 vs. 3.1 ± 1.2), and conspicuity of detected lesions (4.7 ± 0.5 vs. 3.8 ± 1.1; 4.5 ± 0.5 vs. 3.8 ± 1.0). For detecting LR, GRASP also achieved higher sensitivity (70% vs. 36%; 80% vs. 45%), specificity (R1 and R2: 100% vs. 50%), and accuracy (75% vs. 38%; 83% vs. 46%) for both readers.

CONCLUSION:

Although requiring larger studies, high spatiotemporal resolution GRASP achieved substantially better image quality and diagnostic performance than standard DCE for detecting LR in patients with elevated PSA after prostatectomy.

• Authors: Andrew B Rosenkrantz, Anunita Khasgiwala, Ankur M Doshi, Justin M Ream, Samir S Taneja, Herbert Lepor
• Journal: Abdominal radiology (New York) (Abdom Radiol (NY)) Vol. 42 Issue 1 Pg. 290-297 (01 2017) ISSN: 2366-0058 [Electronic] United States
• PMID: 27576605 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contrast Media

Topics

• Aged
• Aged, 80 and over
• Contrast Media
• Humans
• Image Interpretation, Computer-Assisted
• Magnetic Resonance Imaging (methods)
• Male
• Middle Aged
• Neoplasm Recurrence, Local (diagnostic imaging, pathology)
• Prostatectomy (methods)
• Prostatic Neoplasms (diagnostic imaging, pathology, surgery)
• Retrospective Studies