Abstract | BACKGROUND AND PURPOSE: METHODS: Thirty-four patients fulfilling either the Armstrong or the Boeve criteria were assessed with [18 F]- 2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) and/or [123 I]- Ioflupane single-photon-emission-computed tomography (SPECT) for DAT availability. A small subset of patients had also undergone D2/3 receptor imaging. Imaging data were analyzed using both statistical parametric mapping and a volume-of-interest-based approach relative to data from healthy controls. RESULTS: Significant reductions of the cortical glucose metabolism were observed in the central region and the adjacent frontal and parietal association areas contralateral to the side with predominant motor symptoms. Reductions were also evident in the basal ganglia, notably in the putamen contralateral to the clinically affected side, and in the bilateral thalamus. DAT availability was reduced bilaterally, most distinctly on the side contralateral to the main motor symptoms. CONCLUSIONS: We replicated and refined earlier findings of impaired glucose metabolism and nigrostriatal degeneration in CBS, highlighting asymmetric cortical and subcortical hypometabolism, symmetrically reduced metabolism in the thalamus, and only a slightly asymmetric reduction in DAT, while D2/3 receptors seem to be mainly preserved. These results provide systematic evidence for the usefulness of FDG PET and dopaminergic SPECT imaging to characterize CBS.
|
Authors | Erik Mille, Johannes Levin, Matthias Brendel, Christian Zach, Henryk Barthel, Osama Sabri, Kai Bötzel, Peter Bartenstein, Adrian Danek, Axel Rominger |
Journal | Journal of neuroimaging : official journal of the American Society of Neuroimaging
(J Neuroimaging)
Vol. 27
Issue 2
Pg. 255-261
(03 2017)
ISSN: 1552-6569 [Electronic] United States |
PMID | 27572945
(Publication Type: Journal Article)
|
Copyright | Copyright © 2016 by the American Society of Neuroimaging. |
Chemical References |
- Dopamine Plasma Membrane Transport Proteins
- Nortropanes
- Radiopharmaceuticals
- Receptors, Dopamine
- Fluorodeoxyglucose F18
- Glucose
- ioflupane
- Dopamine
|
Topics |
- Aged
- Aged, 80 and over
- Brain
(metabolism)
- Dopamine
(metabolism)
- Dopamine Plasma Membrane Transport Proteins
(metabolism)
- Female
- Fluorodeoxyglucose F18
- Glucose
(metabolism)
- Humans
- Male
- Middle Aged
- Neurodegenerative Diseases
(metabolism)
- Nortropanes
- Positron-Emission Tomography
- Radiopharmaceuticals
- Receptors, Dopamine
(metabolism)
- Syndrome
- Tomography, Emission-Computed, Single-Photon
|