Comparisons of clinicopathologic factors and survival rates between laparoscopic and open gastrectomy in gastric cancer.

Abstract

PURPOSE:

This study examined the safety and facilitative aspects of laparoscopic gastrectomy, with respect to clinicopathologic factors and complications in patients with gastric cancer, in comparison with open gastrectomy. The study also compared the safety of laparoscopic gastrectomy, with respect to the 5-year survival rate and recurrence in terms of the oncologic results, with that of open gastrectomy.

METHODS:

This retrospective study included 424 patients with gastric cancer who had undergone gastrectomy at Busan Paik Hospital, Inje University, over a 5-year period from January 2010 to December 2014. The gastric cancer database, comprising data collected from the patients' medical records, was examined for the analysis of clinicopathologic factors, complications, survival rates, and recurrence.

RESULTS:

Of the 424 patients, 146 underwent laparoscopic gastrectomy and 278 underwent open gastrectomy. Differences were observed between laparoscopic and open gastrectomy with respect to clinicopathologic features such as tumor size, number of harvested lymph nodes, differentiation, T stage, N stage, TNM stage, lymphatic invasion, vascular invasion, and perineural invasion. The complication rates of laparoscopic and open gastrectomy were 4.8% and 4.3%, respectively, and the recurrence rates were 3.4% and 11.5%, respectively. The 5-year overall survival rates (OSRs) of laparoscopic and open gastrectomy were 90.5% and 85.9%, respectively, and the 5-year disease-free survival rates (DFSRs) were 90.2% and 75.6%, respectively, with significant differences. The 5-year OSRs of laparoscopic and open gastrectomy for stage I disease were 96.6% and 96.9%, respectively, those for stage II disease were 44.4% and 97.7%, respectively, and those for stage III disease were 75.0% and 61.7%, respectively. The 5-year DFSRs of laparoscopic and open gastrectomy for stage I disease were 95.4% and 96.9%, respectively, those for stage II disease were 60.6% and 84.9%, respectively, and those for stage III disease were 64.3% and 40.1%, respectively, with no significant difference.

CONCLUSION:

This study showed that laparoscopic gastrectomy is a safe and beneficial modality compared with open gastrectomy in patients with gastric cancer. In terms of the oncologic results, laparoscopic gastrectomy is also considered safe and provides the same results as open gastrectomy.

• Authors: Dong Jun Kim, Sang Hyuk Seo, Kwang Hee Kim, Yo-Han Park, Min Sung An, Ki Beom Bae, Chang Soo Choi, Sang Hoon Oh
• Journal: International journal of surgery (London, England) (Int J Surg) Vol. 34 Pg. 161-168 (Oct 2016) ISSN: 1743-9159 [Electronic] United States
• PMID: 27568651 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2016 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.

Topics

• Aged
• Disease-Free Survival
• Female
• Gastrectomy (methods, mortality)
• Humans
• Laparoscopy (methods, mortality)
• Male
• Middle Aged
• Neoplasm Staging
• Retrospective Studies
• Stomach Neoplasms (mortality, pathology, surgery)
• Survival Rate
• Treatment Outcome