Abstract | OBJECTIVE: We conducted the present study to elucidate the clinical presentation, treatment outcomes and risk factors for the development of metachronous brain metastasis at a single progressive disease site, the so-called isolated brain metastasis, in patients with testicular germ cell tumors. METHODS: To identify metachronous brain metastasis in a timely manner, brain imaging was performed when the re-elevation of tumor markers was observed during chemotherapy, even in patients who were free from central nervous system symptoms. The medical records of 147 patients with metastatic germ cell tumors who were treated between 1991 and 2015 were retrospectively reviewed. RESULTS: CONCLUSIONS: In our series, we identified isolated brain metastasis in 57% of the metachronous brain metastasis patients. The monitoring of tumor markers and appropriate brain imaging are mandatory for the diagnosis of isolated brain relapse, which is associated with a higher rate of long-term survival.
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Authors | Takashi Kawahara, Koji Kawai, Takayuki Yoshino, Atsushi Ikeda, Ryutarou Ishizuka, Shuya Kandori, Ei-Ichirou Takaoka, Takahiro Kojima, Akira Joraku, Takahiro Suetomi, Jun Miyazaki, Hiroyuki Nishiyama |
Journal | Japanese journal of clinical oncology
(Jpn J Clin Oncol)
Vol. 46
Issue 11
Pg. 1047-1052
(Nov 01 2016)
ISSN: 1465-3621 [Electronic] England |
PMID | 27566974
(Publication Type: Journal Article)
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Copyright | © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: [email protected]. |