Fetal anemia, cerebellar hemorrhage and hypoplasia associated with congenital Parvovirus infection.

Abstract

We report a case of fetal cerebellar hemorrhage and hypoplasia, identified by fetal MRI after intrauterine blood transfusion at 21 weeks' gestation for treatment of severe anemia due to congenital Parvovirus infection. Postnatal MRI confirmed atrophy of bilateral cerebellar hemispheres and inferior vermis. Cerebellar capillaries may be extremely susceptible to hemodynamic changes in the setting of intrauterine blood transfusion due to severe anemia. Although the correlation between fetal intracranial anomalies and Parvovirus infection remains unclear, in this population, a detailed evaluation of the brain parenchyma should be considered prior to and after intrauterine blood transfusion.

• Authors: Laura Sanapo, Michael Wien, Matthew T Whitehead, Anna Blask, Michael Gallagher, Roberta L DeBiasi, Adre Du Plessis
• Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (J Matern Fetal Neonatal Med) Vol. 30 Issue 16 Pg. 1887-1890 (Aug 2017) ISSN: 1476-4954 [Electronic] England
• PMID: 27558443 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Anemia (therapy, virology)
• Blood Transfusion, Intrauterine
• Cerebellum (abnormalities, diagnostic imaging, virology)
• Developmental Disabilities (diagnostic imaging, virology)
• Diffusion Magnetic Resonance Imaging
• Female
• Fetal Diseases (diagnostic imaging, virology)
• Humans
• Intracranial Hemorrhages (diagnostic imaging, virology)
• Nervous System Malformations (diagnostic imaging, virology)
• Parvoviridae Infections (complications, congenital, diagnostic imaging)
• Pregnancy