The oncological outcome after lung
metastasis in patients with
chondrosarcoma of the extremities has not been reported. Between June 2000 and June 2013, 179 patients with
chondrosarcoma in the extremities were treated at eleven hospitals. Twenty consecutive patients (11.2%) developed lung
metastases after initial treatment of primary
chondrosarcoma in the extremities. We investigated the oncological outcome of 20
chondrosarcoma patients with lung
metastasis. There were 14 males and six females with a mean age of 49 years. The mean duration between primary surgery and appearance of lung
metastases was 34 months. The mean follow-up period was 48 months. We excluded patients with lung
metastasis at the time of presentation from this study. At the final follow-up, four of 20 patients had no evidence of disease, four were alive with disease, and twelve had died of disease. The 3- and 5-year survival rates after lung
metastasis were 51.5% and 45.7%, respectively.
Tumor grade, extrapulmonary
metastasis, and treatment for lung
metastases including
metastasectomy and
radiofrequency ablation were identified by univariate analysis to be significant prognostic factors for oncological analysis. In conclusion, this study evaluated the oncological outcome in patients with
chondrosarcoma of the extremities with lung
metastasis. Although a large-scale study might be required to confirm the results of this study, we suggest that
metastasectomy and/or
radiofrequency ablation should be considered to improve postmetastatic survival.