Commentary: Are alpha-2 agonist really effective in children with tics with comorbid ADHD? A commentary on Whittington et al. (2016).

Abstract

In this issue, Whittington et al. (2016) present a systematic review that reports the efficacy of three primary treatments for children with Tourette syndrome (TS) - (a) α2-adrenergic receptor agonists; (b) antipsychotic medications; and (c) habit reversal training/comprehensive behavioral intervention. In this commentary, we highlight the large degree of heterogeneity observed in the meta-analysis of trials involving alpha-2 agonist medications and present possible explanations for the observed heterogeneity. Among these possible explanations is the possibility that presence of comorbid ADHD may moderate the efficacy of alpha-2 agonists in the treatment of tic disorder with the medications being more effective in patients with both conditions. The commentary reviews the evidence supporting this possible moderating effect of ADHD and discusses the implications for such a relationship.

• Authors: Michael H Bloch
• Journal: Journal of child psychology and psychiatry, and allied disciplines (J Child Psychol Psychiatry) Vol. 57 Issue 9 Pg. 1005-7 (09 2016) ISSN: 1469-7610 [Electronic] England
• PMID: 27535650 (Publication Type: Journal Article, Comment)
• Copyright: © 2016 Association for Child and Adolescent Mental Health.

Topics

• Attention Deficit Disorder with Hyperactivity
• Child
• Comorbidity
• Humans
• Tic Disorders
• Tics
• Tourette Syndrome