Impact of Maspin Polymorphism rs2289520 G/C and Its Interaction with Gene to Gene, Alcohol Consumption Increase Susceptibility to Oral Cancer Occurrence.

Abstract

BACKGROUND:

The purpose of this study was to identify gene polymorphisms of mammary serine protease inhibitor (Maspin) specific to patients with oral cancer susceptibility and clinicopathological status.

METHODOLOGY/PRINCIPAL FINDINGS:

Three single-nucleotide polymorphisms (SNPs) of the Maspin gene from 741 patients with oral cancer and 601 non-cancer controls were analyzed by real-time PCR. The participants with G/G homozygotes or with G/C heterozygotes of Maspin rs2289520 polymorphism had a 2.07-fold (p = 0.01) and a 2.01-fold (p = 0.02) risk of developing oral cancer compared to those with C/C homozygotes. Moreover, gene-gene interaction increased the risk of oral cancer susceptibility among subjects expose to oral cancer related risk factors, including areca, alcohol, and tobacco consumption.

CONCLUSION:

G allele of Maspin rs2289520 polymorphism may be a factor that increases the susceptibility to oral cancer. The interactions of gene to oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.

• Authors: Po-Yu Yang, Nae-Fang Miao, Chiao-Wen Lin, Ying-Erh Chou, Shun-Fa Yang, Hui-Chuan Huang, Hsiu-Ju Chang, Hsiu-Ting Tsai
• Journal: PloS one (PLoS One) Vol. 11 Issue 8 Pg. e0160841 ( 2016) ISSN: 1932-6203 [Electronic] United States
• PMID: 27525723 (Publication Type: Journal Article)

Chemical References

• SERPIN-B5
• Serpins

Topics

• Alcohol Drinking (adverse effects)
• Case-Control Studies
• Epistasis, Genetic
• Female
• Genetic Predisposition to Disease (genetics)
• Humans
• Male
• Middle Aged
• Mouth Neoplasms (genetics, pathology)
• Polymorphism, Single Nucleotide
• Serpins (genetics)