Long-lasting Localized Pemphigus Vulgaris without Detectable Serum Autoantibodies Against Desmoglein 3 and Desmoglein 1.

Abstract

Pemphigus vulgaris (PV) is an autoimmune blistering disease elicited by anti-desmoglein (DsG) 3 antibody. Although skin lesions tend to be distributed over the entire body, in some patients, they are confined to a restricted area. We report two patients who presented with long-lasting localized PV without detectable anti-DsG antibodies after suffering antibody-positive systemic PV. Initial treatment with prednisolone (PSL) was successful in both patients, but a local relapse occurred on the cheek or lower lip after a reduction in the PSL dose. Biopsy of the localized lesions showed suprabasal acantholysis; no serum DsG antibodies were found. Local immunosuppression therapy was effective in both patients. Based on our findings, we suggest that localized PV without detectable antibodies can develop after systemic PV.

• Authors: Asuka Yoshifuku, Kazuyasu Fujii, Hisao Kawahira, Hiromi Katsue, Atsunori Baba, Yuko Higashi, Yumi Aoyama, Takuro Kanekura
• Journal: Indian journal of dermatology (Indian J Dermatol) 2016 Jul-Aug Vol. 61 Issue 4 Pg. 427-9 ISSN: 1998-3611 [Electronic] India
• PMID: 27512189 (Publication Type: Journal Article)