The role of DOG1 immunohistochemistry in dermatopathology.

Abstract

BACKGROUND:

This study was designed to evaluate the immunoexpression of DOG1, a specific marker expressed in gastrointestinal stromal tumors, in normal skin tissues and cutaneous epithelial tumors.

METHODS:

DOG1 immunostaining extent, intensity and pattern were evaluated in 69 cutaneous apocrine/eccrine tumors, 11 sebaceous tumors, 46 follicular tumors, 52 keratinocytic tumors and perilesional normal tissues.

RESULTS:

In normal tissues, DOG1 was expressed strongly in the intercellular canaliculi of eccrine glands, moderately in the myoepithelial cells of mammary and anogenital mammary-like glands, and weakly or not at all in the periphery of sebaceous lobules and the lower layer of epidermis and follicular infundibulum. All apocrine-type cutaneous mixed tumors showed apical-luminal positivity for DOG1, and 4/9 of these tumors included intercellular canaliculi highlighted by DOG1 immunostaining. Other sweat gland tumors, including hidrocystadenoma, spiradenoma, cylindroma and apocrine carcinoma, also expressed DOG1 focally with an apical-luminal pattern. Although slight membranous positivity for DOG1 was observed in various tumor types, hidradenoma papilliferum exhibited diffuse membranous DOG1 staining in the myoepithelial cells.

CONCLUSIONS:

DOG1 is a novel marker for identifying intercellular canaliculi and is a potential immunomarker of myoepithelial cells specific to mammary glands, anogenital mammary-like glands and tumors originating therein.

• Authors: Keisuke Goto
• Journal: Journal of cutaneous pathology (J Cutan Pathol) Vol. 43 Issue 11 Pg. 974-983 (Nov 2016) ISSN: 1600-0560 [Electronic] United States
• PMID: 27506854 (Publication Type: Journal Article)
• Copyright: © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• ANO1 protein, human
• Anoctamin-1
• Biomarkers, Tumor
• Chloride Channels
• Neoplasm Proteins

Topics

• Anoctamin-1
• Biomarkers, Tumor (metabolism)
• Chloride Channels (metabolism)
• Diagnosis, Differential
• Gastrointestinal Neoplasms (metabolism)
• Gastrointestinal Stromal Tumors (metabolism)
• Humans
• Immunohistochemistry
• Neoplasm Proteins (metabolism)
• Skin (metabolism)
• Skin Neoplasms (metabolism)