Abstract | BACKGROUND: METHODS: A total of 31 patients received a Syncardia Total Artificial Heart. Preoperatively 17 patients exhibited normal liver function or mild hepatic derangements that were clinically insignificant and did not qualify as acute or chronic liver failure, 5 patients exhibited ALF and 9 various hepatic derangements owing to CH. Liver associated mortality and postoperative course of liver values were prospectively documented and retrospectively analyzed. RESULTS: Liver associated mortality in normal liver function, ALF and CH cases was 0%, 20% (P=0.03) and 44.4% (P=0.0008) respectively. 1/17 (5.8%) patients with a normal liver function developed an ALF, 4/5 (80%) patients with an ALF experienced a markedly improvement of hepatic function and 6/9 (66.6%) patients with CH a significant deterioration. CONCLUSIONS: TAH therapy results in recovery of hepatic function in ALF cases. Patients with CH prior to surgery form a high risk group with increased liver associated mortality.
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Authors | Alexandros Merkourios Dimitriou, Otto Dapunt, Igor Knez, Andrae Wasler, Peter Oberwalder, Reiner Koerfer, Gero Tenderich, Sotirios Spiliopoulos |
Journal | Journal of thoracic disease
(J Thorac Dis)
Vol. 8
Issue 7
Pg. 1546-9
(Jul 2016)
ISSN: 2072-1439 [Print] China |
PMID | 27499942
(Publication Type: Journal Article)
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