Sustained remission after long-term biological therapy in patients with large vessel vasculitis: an analysis of ten cases.

Abstract

OBJECTIVES:

To describe the results obtained in clinical practice with the use of biological therapy (BT) in patients diagnosed with Takayasu arteritis (TA) and giant cell arteritis (GCA).

METHODS:

Retrospective single center study of TA/GCA patients who received BT (infliximab [IFX], etanercept [ETN] and tocilizumab [TCZ]). In TA, active disease was defined according to a previous National Institutes of Health study. In GCA, active disease was defined with a modified criteria and clinical manifestations secondary to temporal artery involvement or polymyalgia rheumatica symptoms. Clinical data and outcomes are reported using descriptive statistics.

RESULTS:

Five patients with TA and 5 with GCA were included. The main reason for starting BT was lack of response to prior therapy and/or ≥2 relapses during GC tapering. Five patients started IFX, four TCZ and 1 ETN. Remission was observed before 6 months in all cases. Only one patient had a relapse during long-term follow-up and the overall GC daily dose was reduced by 70%. Two AEs were considered attributable to IFX and one to TCZ.

CONCLUSION:

A favorable and sustained response to BT was observed in our patients with TA and GCA. Thus, BT might be considered as an alternative in patients with large vessel arteritis refractory to conventional treatment or with GC related comorbidities.

• Authors: Juan P Vinicki, Rosario García-Vicuña, Miguel Arredondo, Juan P López-Bote, Jesús A García-Vadillo, Santos Castañeda, José M Álvaro-Gracia
• Journal: Reumatologia clinica (Reumatol Clin) 2017 Jul - Aug Vol. 13 Issue 4 Pg. 210-213 ISSN: 1885-1398 [Electronic] Spain
• PMID: 27499427 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.

Chemical References

• Antibodies, Monoclonal, Humanized
• Immunosuppressive Agents
• Infliximab
• tocilizumab
• Etanercept

Topics

• Adult
• Aged
• Aged, 80 and over
• Antibodies, Monoclonal, Humanized (therapeutic use)
• Biological Therapy
• Etanercept (therapeutic use)
• Female
• Follow-Up Studies
• Giant Cell Arteritis (drug therapy)
• Humans
• Immunosuppressive Agents (therapeutic use)
• Induction Chemotherapy
• Infliximab (therapeutic use)
• Male
• Middle Aged
• Retrospective Studies
• Takayasu Arteritis (drug therapy)
• Treatment Outcome