Children, especially infants, are highly vulnerable to
iron-deficiency anemia because of their rapid growth of the brain and the rest of the body. The objectives of this study were to compare the prevalence of
iron-deficiency anemia in infants born from HIV-positive mothers and HIV-negative mothers and to identify the determinants of
iron-deficiency anemia in infants.A comparative cross-sectional study was conducted in Bahir Dar city. Simple random sampling technique was used to select the study participants. Mothers were interviewed; blood samples were collected from mothers and infants to measure the
hemoglobin level and anthropometric indicators were obtained from the infants using world health organization standards. Descriptive statistics were used to estimate the prevalence of infantile
anemia. Binary logistic regression and multiple linear regressions were used to identify the determinants of infant
anemia.A total of 1459 infants born from HIV-positive and HIV-negative mothers were included. The prevalence of
iron-deficiency anemia in infants born from HIV-positive and HIV-negative mothers was 41.9% (95% CI: 39-44). Infantile
iron-deficiency anemia was associated with maternal
HIV infection (adjusted odds ratio [AOR] 2.54 [95% CI: 1.65-3.9]),
stunting (AOR 3.46 [95% CI: 2.41-4.97]), low income (AOR 2.72 [95% CI: 2-3.73]), maternal
malaria during pregnancy (AOR 1.81 [95% CI: 1.33-2.47]), use of cow milk before 6 month (AOR 1.82 [95% CI: 1.35-2.45]), residence (AOR 0.09 [95% CI: 0.06-0.13]), history of
cough or
fever 7 days preceding the survey (AOR 2.71 [95% CI: 1.99-3.69]), maternal
hemoglobin (B 0.65 [95% CI: 0.61-0.68]), educational status of mother (B 0.22 [95% CI: 0.2-0.23]), age of the mother (B -0.03 [95% CI: -0.03, -0.02]), and family size (B -0.14 [95% CI: -0.18,-0.11]).