Abstract | BACKGROUND: METHODS: Eighteen anesthetized and mechanically ventilated sheep were subjected to a multimodal hemodynamic/perfusion assessment including hepatic and portal vein catheterizations, total hepatic blood flow, and muscle microdialysis. After monitoring, all received a bolus and continuous infusion of endotoxin. After 1 h they were volume resuscitated, and then randomized to endotoxin-control, endotoxin- dexmedetomidine (sequential doses of 0.5 and 1.0 μg/k/h) or endotoxin- esmolol (titrated to decrease basal heart rate by 20 %) groups. Samples were taken at four time points, and exogenous lactate clearance using an intravenous administration of sodium L- lactate (1 mmol/kg) was performed at the end of the experiments. RESULTS: CONCLUSIONS:
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Authors | Glenn Hernández, Pablo Tapia, Leyla Alegría, Dagoberto Soto, Cecilia Luengo, Jussara Gomez, Nicolas Jarufe, Pablo Achurra, Rolando Rebolledo, Alejandro Bruhn, Ricardo Castro, Eduardo Kattan, Gustavo Ospina-Tascón, Jan Bakker |
Journal | Critical care (London, England)
(Crit Care)
Vol. 20
Issue 1
Pg. 234
(08 02 2016)
ISSN: 1466-609X [Electronic] England |
PMID | 27480413
(Publication Type: Journal Article)
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Chemical References |
- Propanolamines
- Lactic Acid
- Dexmedetomidine
- esmolol
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Topics |
- Animals
- Chile
- Dexmedetomidine
(adverse effects, pharmacokinetics, therapeutic use)
- Heart Rate
(drug effects)
- Hemodynamics
(drug effects, physiology)
- Hyperlactatemia
(etiology, physiopathology)
- Lactic Acid
(blood, metabolism)
- Models, Animal
- Propanolamines
(adverse effects, pharmacokinetics, therapeutic use)
- Sheep
(metabolism)
- Shock, Septic
(drug therapy)
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