Ciprofloxacin versus colistin prophylaxis during neutropenia in acute myeloid leukemia: two parallel patient cohorts treated in a single center.

Abstract

Patients undergoing intensive chemotherapy for acute myeloid leukemia are at high risk for bacterial infections during therapy-related neutropenia. However, the use of specific antibiotic regimens for prophylaxis in afebrile neutropenic acute myeloid leukemia patients is controversial. We report a retrospective evaluation of 172 acute myeloid leukemia patients who received 322 courses of myelosuppressive chemotherapy and had an expected duration of neutropenia of more than seven days. The patients were allocated to antibiotic prophylaxis groups and treated with colistin or ciprofloxacin through 2 different hematologic services at our hospital, as available. The infection rate was reduced from 88.6% to 74.2% through antibiotic prophylaxis (vs without prophylaxis; P=0.04). A comparison of both antibiotic drugs revealed a trend towards fewer infections associated with ciprofloxacin prophylaxis (69.2% vs 79.5% in the colistin group; P=0.07), as determined by univariate analysis. This result was confirmed through multivariate analysis (OR: 0.475, 95%CI: 0.236-0.958; P=0.041). The prophylactic agents did not differ with regard to the microbiological findings (P=0.6, not significant). Of note, the use of ciprofloxacin was significantly associated with an increased rate of infections with pathogens that are resistant to the antibiotic used for prophylaxis (79.5% vs 9.5% in the colistin group; P<0.0001). The risk factors for higher infection rates were the presence of a central venous catheter (P<0.0001), mucositis grade III/IV (P=0.0039), and induction/relapse courses (vs consolidation; P<0.0001). In conclusion, ciprofloxacin prophylaxis appears to be of particular benefit during induction and relapse chemotherapy for acute myeloid leukemia. To prevent and control drug resistance, it may be safely replaced by colistin during consolidation cycles of acute myeloid leukemia therapy.

• Authors: Michele Pohlen, Julia Marx, Alexander Mellmann, Karsten Becker, Rolf M Mesters, Jan-Henrik Mikesch, Christoph Schliemann, Georg Lenz, Carsten Müller-Tidow, Thomas Büchner, Utz Krug, Matthias Stelljes, Helge Karch, Georg Peters, Hans U Gerth, Dennis Görlich, Wolfgang E Berdel
• Journal: Haematologica (Haematologica) Vol. 101 Issue 10 Pg. 1208-1215 (10 2016) ISSN: 1592-8721 [Electronic] Italy
• PMID: 27470601 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright© Ferrata Storti Foundation.

Chemical References

• Anti-Bacterial Agents
• Antineoplastic Agents
• Ciprofloxacin
• Colistin

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Anti-Bacterial Agents (therapeutic use)
• Antibiotic Prophylaxis (methods)
• Antineoplastic Agents (adverse effects)
• Bacterial Infections (drug therapy, prevention & control)
• Central Venous Catheters (adverse effects)
• Ciprofloxacin (administration & dosage)
• Cohort Studies
• Colistin (administration & dosage)
• Female
• Humans
• Leukemia, Myeloid, Acute (complications, drug therapy)
• Male
• Middle Aged
• Mucositis (complications)
• Neutropenia (drug therapy, prevention & control)
• Retrospective Studies
• Young Adult