Association between single nucleotide polymorphisms in the TSPYL6 gene and breast cancer susceptibility in the Han Chinese population.

Abstract

We investigated the associations between single nucleotide polymorphisms (SNPs) in the testis-specific Y-encoded-like protein 6 (TSPYL6) gene and breast cancer (BC) susceptibility in the Han Chinese population. A total of 183 BC patients and 195 healthy women were included in the study. Six SNPs in TSPYL6 were genotyped and the association with BC risk analyzed. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression analysis. Multivariate logistic regression analysis was used to identify SNPs that correlated with BC susceptibility. Rs11896604 was associated with a decreased risk of BC based on dominant and genotype models. Rs843706 was associated with an increased risk of BC based on a recessive model. Rs11125529 was associated with decreased BC susceptibility based on a genotype model. Finally, rs843711 inversely correlated with clinical stage III/IV BC. Our findings reveal a significant association between SNPs in the TSPYL6 gene and BC risk in a Han Chinese population.

• Authors: Ming Liu, Bin Li, Wen Guo, Xiyang Zhang, Zhengshuai Chen, Jingjie Li, Mengdan Yan, Chao Chen, Tianbo Jin
• Journal: Oncotarget (Oncotarget) Vol. 7 Issue 34 Pg. 54771-54781 (Aug 23 2016) ISSN: 1949-2553 [Electronic] United States
• PMID: 27458158 (Publication Type: Journal Article)

Topics

• Adult
• Asian People (genetics)
• Breast Neoplasms (ethnology, genetics, pathology)
• China
• Female
• Gene Frequency
• Genetic Predisposition to Disease (ethnology, genetics)
• Genotype
• Humans
• Logistic Models
• Middle Aged
• Multivariate Analysis
• Neoplasm Staging
• Polymorphism, Single Nucleotide